Araya-Quintanilla F, Celis-Rosati A, Rodriguez-Leiva C, Silva-Navarro C, Silva-Pinto Y, Toro-Jeria B
Universidad de las Americas, Santiago de Chile, Chile.
Rev Neurol. 2016 May 16;62(10):439-48.
Epilepsy is a brain disorder that affects both children and adults. From the 1920s the ketogenic diet has gained prestige as another treatment option for patients with refractory epilepsy.
A summary of the evidence will be made through a systematic review of randomized clinical trials that have compared a single ketogenic diet with other diet for the management of these patients.
To determine the effectiveness of the ketogenic diet in reducing episodes of seizures in patients with refractory epilepsy. The search strategy included randomized controlled trials and controlled clinical trials. Databases used were Medline, LILACS, Central and CINAHL.
Six articles that met our elegibility criteria.
There is limited evidence that the ketogenic diet compared to the medium-chain triglyceride diet is more effective in reducing the frequency of seizures. There is also moderate evidence that classical ketogenic diet compared to the gradual diet (2.5:1 and 3:1) is more effective in reducing seizures. There is moderate evidence that classical ketogenic diet compared to Atkins diet is more effective in reducing the frequency of seizure. The decision to apply this type of diet should also be based on costs, preferences and safety of treatment. It should also take into account the likelihood that studies have indexing problems have been left out of the review.
癫痫是一种影响儿童和成人的脑部疾病。从20世纪20年代起，生酮饮食作为难治性癫痫患者的另一种治疗选择而受到重视。
通过对比较单一生酮饮食与其他饮食用于治疗这些患者的随机临床试验进行系统综述，来总结证据。
确定生酮饮食在减少难治性癫痫患者癫痫发作次数方面的有效性。检索策略包括随机对照试验和对照临床试验。使用的数据库有Medline、LILACS、Central和CINAHL。
有6篇文章符合我们的入选标准。
与中链甘油三酯饮食相比，生酮饮食在降低癫痫发作频率方面更有效的证据有限。也有中等证据表明，经典生酮饮食与渐进饮食（2.5:1和3:1）相比，在减少癫痫发作方面更有效。有中等证据表明，经典生酮饮食与阿特金斯饮食相比，在降低癫痫发作频率方面更有效。应用这种饮食类型的决定还应基于成本、治疗偏好和安全性。还应考虑到研究可能存在索引问题而被排除在综述之外的可能性。
