母体暴露组的机制及其对健康结果的影响。
Mechanisms of the Maternal Exposome and Implications for Health Outcomes.
作者信息
Wright Michelle L, Starkweather Angela R, York Timothy P
机构信息
University of Connecticut, School of Nursing, Storrs, Connecticut (Dr Starkweather), Yale University, School of Nursing, West Haven, Connecticut (Dr Wright); and Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human and Molecular Genetics, and Department of Obstetrics and Gynecology, Virginia Commonwealth University School of Medicine, Richmond (Dr York).
出版信息
ANS Adv Nurs Sci. 2016 Apr-Jun;39(2):E17-30. doi: 10.1097/ANS.0000000000000110.
Abstract
It is well established that the environment contributes to health. However, few studies have evaluated environmental exposures in women that may influence future health of their offspring. Knowledge gained may inform nursing how to better advocate for patients and families, and provide individualized interventions and education. Therefore, a more comprehensive investigation of the maternal exposome to uncover mechanistic insight into complex disease in offspring is warranted. To advance understanding of biologic mechanisms that contribute to high-risk birth outcomes and offspring predisposition to disease, it will be necessary to measure a range of exposures and biomarkers before and during pregnancy.
摘要
环境对健康有影响这一点已得到充分证实。然而，很少有研究评估可能影响其后代未来健康的女性所接触的环境因素。所获得的知识可以为护理工作提供指导，使其更好地为患者及其家庭提供支持，并提供个性化的干预措施和教育。因此，有必要对母亲的暴露组进行更全面的调查，以揭示后代复杂疾病的发病机制。为了进一步了解导致高危出生结局和后代疾病易感性的生物学机制，有必要在怀孕前和怀孕期间测量一系列暴露因素和生物标志物。
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