结肠炎相关结肠癌的小鼠模型
Murine Model for Colitis-Associated Cancer of the Colon.
作者信息
Snider Ashley J, Bialkowska Agnieszka B, Ghaleb Amr M, Yang Vincent W, Obeid Lina M, Hannun Yusuf A
机构信息
Northport VA Medical Center, Northport, NY, 11768, USA.
Department of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.
出版信息
Methods Mol Biol. 2016;1438:245-54. doi: 10.1007/978-1-4939-3661-8_14.
Abstract
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), significantly increases the risk for development of colorectal cancer. Specifically, dysplasia and cancer associated with IBD (colitis-associated cancer or CAC) develop as a result of repeated cycles of injury and healing in the intestinal epithelium. Animal models are utilized to examine the mechanisms of CAC, the role of epithelial and immune cells in this process, as well as the development of novel therapeutic targets. These models typically begin with the administration of a carcinogenic compound, and inflammation is caused by repeated cycles of colitis-inducing agents. This review describes a common CAC model that utilizes the pro-carcinogenic compound azoxymethane (AOM) followed by dextran sulfate sodium (DSS) which induces the inflammatory insult.
摘要
炎症性肠病（IBD），包括溃疡性结肠炎（UC）和克罗恩病（CD），会显著增加患结直肠癌的风险。具体而言，与IBD相关的发育异常和癌症（结肠炎相关癌或CAC）是由于肠上皮反复的损伤和愈合循环所致。动物模型用于研究CAC的机制、上皮细胞和免疫细胞在此过程中的作用，以及新型治疗靶点的开发。这些模型通常首先给予致癌化合物，通过反复给予诱导结肠炎的药物引发炎症。本综述描述了一种常见的CAC模型，该模型使用致癌前体化合物氧化偶氮甲烷（AOM），随后使用硫酸葡聚糖钠（DSS）诱导炎症损伤。
相似文献
1
Murine Model for Colitis-Associated Cancer of the Colon.结肠炎相关结肠癌的小鼠模型
Methods Mol Biol. 2016;1438:245-54. doi: 10.1007/978-1-4939-3661-8_14.
2
Modeling colitis-associated cancer with azoxymethane (AOM) and dextran sulfate sodium (DSS).用氧化偶氮甲烷（AOM）和葡聚糖硫酸钠（DSS）建立结肠炎相关癌症模型。
J Vis Exp. 2012 Sep 11(67):4100. doi: 10.3791/4100.
3
Differences in colonic crypt morphology of spontaneous and colitis-associated murine models via second harmonic generation imaging to quantify colon cancer development.通过二次谐波成像定量分析自发性和结肠炎相关的小鼠模型结肠隐窝形态的差异，以研究结肠癌的发生发展。
BMC Cancer. 2019 May 9;19(1):428. doi: 10.1186/s12885-019-5639-8.
4
MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice.微小RNA214与溃疡性结肠炎的进展相关，抑制其表达可减少小鼠结肠炎及结肠炎相关癌症的发生。
Gastroenterology. 2015 Oct;149(4):981-92.e11. doi: 10.1053/j.gastro.2015.05.057. Epub 2015 Jun 6.
5
Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane.葡聚糖硫酸钠对由氧化偶氮甲烷引发的小鼠结肠癌发生的剂量依赖性促进作用。
Histol Histopathol. 2005 Apr;20(2):483-92. doi: 10.14670/HH-20.483.
6
The germ-free mice monocolonization with improves azoxymethane/dextran sulfate sodium induced colitis-associated colorectal cancer.无菌小鼠单定植 可改善氧化偶氮甲烷/葡聚糖硫酸钠诱导的结肠炎相关结直肠癌。
Immunopharmacol Immunotoxicol. 2019 Apr;41(2):207-213. doi: 10.1080/08923973.2019.1569047. Epub 2019 Feb 1.
7
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.上皮细胞 vanin-1 控制结肠炎相关结肠癌模型中炎症驱动的癌变。
Inflamm Bowel Dis. 2010 Jan;16(1):96-104. doi: 10.1002/ibd.21031.
8
inhibits colitis-associated cancer via a negative regulation of intestinal inflammation in azoxymethane/dextran sodium sulfate model.通过在氧化偶氮甲烷/葡聚糖硫酸钠模型中对肠道炎症的负调控抑制结肠炎相关癌症。
World J Gastroenterol. 2020 Nov 21;26(43):6782-6794. doi: 10.3748/wjg.v26.i43.6782.
9
[Changes of expression of miR-155 in colitis-associated colonic carcinogenesis].[miR-155在结肠炎相关结肠癌发生过程中的表达变化]
Zhonghua Zhong Liu Za Zhi. 2014 Apr;36(4):257-62.
10
The epigenetic effects of aspirin: the modification of histone H3 lysine 27 acetylation in the prevention of colon carcinogenesis in azoxymethane- and dextran sulfate sodium-treated CF-1 mice.阿司匹林的表观遗传效应：在偶氮甲烷和葡聚糖硫酸钠处理的CF-1小鼠中预防结肠癌发生过程中组蛋白H3赖氨酸27乙酰化的修饰
Carcinogenesis. 2016 Jun;37(6):616-624. doi: 10.1093/carcin/bgw042. Epub 2016 Apr 9.
引用本文的文献
1
Lactobacillus-based probiotic cocktail inhibits colitis-associated cancer by altering intestinal metabolism.基于乳酸杆菌的益生菌鸡尾酒通过改变肠道代谢来抑制结肠炎相关癌症。
Int J Clin Exp Pathol. 2025 Jul 15;18(7):317-334. doi: 10.62347/USLL6631. eCollection 2025.
2
Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis.AMBRA1在抑制S期进入和肿瘤发生中作用的分子和遗传学证据。
iScience. 2025 Jul 5;28(8):113054. doi: 10.1016/j.isci.2025.113054. eCollection 2025 Aug 15.
3
From oncogenesis to prognosis: the roles of the immunoproteasome in cancer.从肿瘤发生到预后：免疫蛋白酶体在癌症中的作用
Front Immunol. 2025 Jul 8;16:1603816. doi: 10.3389/fimmu.2025.1603816. eCollection 2025.
4
Murine Models of Obesity-Related Cancer Risk.肥胖相关癌症风险的小鼠模型
Cancer Prev Res (Phila). 2025 Jun 13. doi: 10.1158/1940-6207.CAPR-24-0545.
5
Standardization of a Preclinical Colon Cancer Model in Male and Female BALB/c Mice: Macroscopic and Microscopic Characterization from Pre-Neoplastic to Tumoral Lesions.雄性和雌性BALB/c小鼠临床前结肠癌模型的标准化：从癌前病变到肿瘤病变的宏观和微观特征
Biomedicines. 2025 Apr 11;13(4):939. doi: 10.3390/biomedicines13040939.
6
Molecular Mechanisms and Clinical Aspects of Colitis-Associated Cancer in Ulcerative Colitis.溃疡性结肠炎相关结肠癌的分子机制与临床研究进展
Cells. 2025 Jan 22;14(3):162. doi: 10.3390/cells14030162.
7
Gegen Qinlian Decoction Attenuates Colitis-Associated Colorectal Cancer via Suppressing TLR4 Signaling Pathway Based on Network Pharmacology and In Vivo/In Vitro Experimental Validation.基于网络药理学及体内/体外实验验证，葛根芩连汤通过抑制TLR4信号通路减轻结肠炎相关结直肠癌
Pharmaceuticals (Basel). 2024 Dec 25;18(1):12. doi: 10.3390/ph18010012.
8
Cyclomodulins-harboring Escherichia coli isolated from obese and normal-weight subjects induces intestinal dysplasia in a mouse model.从肥胖和正常体重受试者中分离到的携带环调节蛋白的大肠杆菌可在小鼠模型中诱导肠道发育不良。
World J Microbiol Biotechnol. 2024 Nov 2;40(12):371. doi: 10.1007/s11274-024-04176-8.
9
FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.FBXO22 通过调控 mTOR 的 S2448 磷酸化形式的降解来抑制结肠炎和结直肠癌的发生。
Proc Natl Acad Sci U S A. 2024 Nov 5;121(45):e2402035121. doi: 10.1073/pnas.2402035121. Epub 2024 Nov 1.
10
(L.) P. Royen Leaf Mitigates Colitis-Associated Colon Cancer through Anti-inflammatory Modulation in BALB/C Mice.（L.）罗延叶通过对BALB/C小鼠的抗炎调节减轻结肠炎相关结肠癌
Adv Pharmacol Pharm Sci. 2024 Sep 10;2024:1137696. doi: 10.1155/2024/1137696. eCollection 2024.
本文引用的文献
1
Cytokines, IBD, and colitis-associated cancer.细胞因子、IBD 和结肠炎相关癌症。
Inflamm Bowel Dis. 2015 Feb;21(2):409-18. doi: 10.1097/MIB.0000000000000236.
2
Identification of a microRNA landscape targeting the PI3K/Akt signaling pathway in inflammation-induced colorectal carcinogenesis.鉴定靶向炎症诱导结直肠癌变中 PI3K/Akt 信号通路的 microRNA 图谱。
Am J Physiol Gastrointest Liver Physiol. 2014 Feb;306(3):G229-43. doi: 10.1152/ajpgi.00484.2012. Epub 2013 Dec 12.
3
The gut microbiome modulates colon tumorigenesis.肠道微生物组调节结肠肿瘤发生。
mBio. 2013 Nov 5;4(6):e00692-13. doi: 10.1128/mBio.00692-13.
4
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms.炎症相关癌症：肿瘤、免疫细胞和微生物之间的串扰。
Nat Rev Cancer. 2013 Nov;13(11):759-71. doi: 10.1038/nrc3611.
5
Development of an inflammation-associated colorectal cancer model and its application for research on carcinogenesis and chemoprevention.一种炎症相关结直肠癌模型的建立及其在致癌作用和化学预防研究中的应用。
Int J Inflam. 2012;2012:658786. doi: 10.1155/2012/658786. Epub 2012 Feb 28.
6
The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies.用于研究结肠癌发生的AOM/DSS小鼠模型：从发病机制到诊断与治疗研究
J Carcinog. 2011 Mar 24;10:9. doi: 10.4103/1477-3163.78279.
7
Animal models of colitis-associated carcinogenesis.结肠炎相关致癌作用的动物模型。
J Biomed Biotechnol. 2011;2011:342637. doi: 10.1155/2011/342637. Epub 2011 Jan 12.
8
Immunity, inflammation, and cancer.免疫、炎症与癌症。
Cell. 2010 Mar 19;140(6):883-99. doi: 10.1016/j.cell.2010.01.025.
9
Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression.Netrin-1 的上调在炎症性肠病中是结直肠癌进展所必需的。
Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17146-51. doi: 10.1073/pnas.0901767106. Epub 2009 Aug 31.
10
Colorectal carcinogenesis: Review of human and experimental animal studies.结直肠癌发生：人类和实验动物研究综述
J Carcinog. 2009;8:5. doi: 10.4103/1477-3163.49014.
Zotero 插件