[75硒]双-[β-(N,N,N-三甲基氨基)乙基]硒二碘化物在成年豚鼠体内的生物分布。
The biodistribution of [75Se]bis-[beta-(N,N,N-trimethylamino)ethyl]selenide diiodide in adult guinea pigs.
作者信息
Yu W K, Shaw S M, Bartlett J M, Van Sickle D C, Mock B H
机构信息
School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana.
出版信息
Int J Rad Appl Instrum B. 1989;16(3):255-9. doi: 10.1016/0883-2897(89)90006-8.
The biodistribution of [75Se]BISTAES was studied in guinea pigs. A higher concentration of radioactivity was observed in articular cartilage than in other tissues or organs. A minimal amount of radioactivity was found in the blood, muscle and bone. The compound was excreted rapidly in urine. The target to background ratios were encouraging. [75Se]BISTAES has potential as an articular cartilage imaging agent and further studies in osteoarthritic animals are merited.
在豚鼠体内研究了[75硒]BISTAES的生物分布。观察到关节软骨中的放射性浓度高于其他组织或器官。在血液、肌肉和骨骼中发现的放射性极少。该化合物经尿液快速排泄。靶本底比令人鼓舞。[75硒]BISTAES有潜力作为一种关节软骨成像剂，值得在骨关节炎动物中进一步研究。
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