双-[β-(N,N,N-三甲基氨基)乙基]硒化物-75Se二碘化物的生物分布，一种潜在的关节软骨成像剂。
Biodistribution of bis-[beta-(N,N,N-trimethylamino)ethyl]selenide-75Se diiodide, a potential articular cartilage imaging agent.
作者信息
Yu W K, Bartlett J M, van Sickle D C, Mock B H
机构信息
School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana.
出版信息
Int J Rad Appl Instrum B. 1988;15(2):229-30. doi: 10.1016/0883-2897(88)90093-1.
In an effort to develop a specific radiodiagnostic agent for articular cartilage imaging, we have investigated the biodistribution of bis[beta-(N,N,N-trimethylamino)ethyl]-selenide-75Se diiodide (75Se BISTAES) in rabbits. At an intravenous dose of 5 mg/kg, the greatest localization of the compound occurred in articular cartilage 15 min after injection. The compound was excreted rapidly in the urine. The results suggest that 75Se BISTAES has potential clinical use as an articular cartilage imaging agent.
为了开发一种用于关节软骨成像的特定放射性诊断剂，我们研究了双[β-(N,N,N-三甲基氨基)乙基]-硒-75Se二碘化物（75Se BISTAES）在兔体内的生物分布。静脉注射剂量为5 mg/kg时，注射后15分钟该化合物在关节软骨中的定位最为明显。该化合物经尿液迅速排泄。结果表明，75Se BISTAES作为关节软骨成像剂具有潜在的临床应用价值。
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