Technetium-99m complexes of dimethylaminomethylene diphosphonate (DMAD)--I. Anion exchange HPLC characterization of 99mTc(NaBH4)-DMAD mixtures.
作者信息
Holland M E, Heineman W R, Deutsch E
机构信息
Department of Chemistry, University of Cincinnati, OH 45221.
出版信息
Int J Rad Appl Instrum B. 1989;16(3):301-11. doi: 10.1016/0883-2897(89)90012-3.
PMID:2715016
Abstract
Radiopharmaceutical analogs prepared by sodium borohydride reduction of 99mTcO4- in the presence of DMAD have been characterized by anion exchange HPLC (high performance liquid chromatography) separation of the resulting mixture into component 99mTc-DMAD complexes. The distribution of complexes within a radiopharmaceutical formulation can be manipulated by controlling technetium concentration, pH, presence or absence of air, and time post reaction.
摘要
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