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In vivo distributions of some component fractions of Tc(NaBH4)-HEDP mixtures separated by anion exchange high performance liquid chromatography.

作者信息

Pinkerton T C, Ferguson D L, Deutsch E, Heineman W R, Libson K

出版信息

Int J Appl Radiat Isot. 1982 Oct;33(10):907-15. doi: 10.1016/0020-708x(82)90136-3.

DOI:10.1016/0020-708x(82)90136-3
PMID:6818160
Abstract

Anion exchange high performance liquid chromatography has been utilized to separate the component Tc-HEDP complexes of "carrier added" as well as "no carrier added" 99mTc(NaBH4)-HEDP reaction mixtures. The chromatographically separated "carrier added" Tc-HEDP components exhibit distinctly different biodistributions which are directly related to the chromatographic characteristics of the individual components. The Tc-HEDP complexes with shortest retention times, and therefore the lowest negative "charge density" have the maximum uptake on the bone, minimum uptake in the kidney, and fastest blood clearance.

摘要

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