Technetium-99m complexes of dimethylaminomethylene diphosphonate (DMAD)--II. Biological distributions of 99mTc-DMAD components isolated by anion exchange HPLC.
作者信息
Holland M E, Bugaj J, Heineman W R, Deutsch E
机构信息
Department of Chemistry, University of Cincinnati, OH 45221.
出版信息
Int J Rad Appl Instrum B. 1989;16(3):313-7. doi: 10.1016/0883-2897(89)90013-5.
PMID:2497091
Abstract
HPLC isolated components of 99mTc(NaBH4)-DMAD mixtures exhibit significantly different biological properties than do analogous components of 99mTc(NaBH4)-MDP and 99mTc(NaBH4)-HEDP mixtures. Most importantly, 99mTc-DMAD components desorb from normal bone whereas analogous 99mTc-MDP and 99mTc-HEDP components do not. However, within an osteogenic rat model, an HPLC isolated 99mTc-DMAD component does not exhibit an unusually high abnormal/normal tibia uptake ratio.
摘要
Zotero 插件