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[输血对结直肠癌患者生存的影响]

[Effect of blood transfusions on the survival of patients with colorectal cancers].

作者信息

Klingler K, Zhang X, Menghini T, Metzger U, Largiadèr F

出版信息

Helv Chir Acta. 1989 Jan;55(5):685-8.

PMID:2715032
Abstract

Blood transfusion is reported to cause immunosuppression. An adverse relationship between perioperative blood transfusions and the risk of subsequent recurrence of cancer was reported recently. We reviewed the records of 282 patients and analyzed the interaction between blood tranfusion and the outcome of Dukes stages A, B and C colorectal cancers treated by radical resection during the years 1978-1985. 53 of these patients did not receive any blood transfusions. The actuarial survival analysis (Cutler and Ederer) showed no significant difference for the overall and recurrence-free survival. This study did not support the hypothesis that blood transfusions had an adverse effect on survival of patients with colorectal cancer.

摘要

据报道,输血会导致免疫抑制。最近有报道称围手术期输血与随后癌症复发风险之间存在不良关系。我们回顾了282例患者的记录,并分析了1978年至1985年期间接受根治性切除的杜克A、B和C期结直肠癌患者输血与治疗结果之间的相互作用。其中53例患者未接受任何输血。精算生存分析(卡特勒和埃德勒法)显示总体生存率和无复发生存率无显著差异。本研究不支持输血对结直肠癌患者生存有不良影响这一假说。

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