通过短寿命C-O轴手性烯醇盐的分子内共轭加成实现多取代二氢苯并呋喃的不对称合成。
Asymmetric Synthesis of Multisubstituted Dihydrobenzofurans by Intramolecular Conjugate Addition of Short-Lived C-O Axially Chiral Enolates.
作者信息
Tomohara Keisuke, Kasamatsu Koji, Yoshimura Tomoyuki, Furuta Takumi, Kawabata Takeo
机构信息
Institute for Chemical Research, Kyoto University.
出版信息
Chem Pharm Bull (Tokyo). 2016 Jul 1;64(7):899-906. doi: 10.1248/cpb.c16-00272. Epub 2016 May 3.
PMID:27150792
Abstract
Enantioselective intramolecular conjugate addition reactions of short-lived C-O axially chiral enolates have been developed. The reactions proceeded with inversion of the configuration and provided dihydrobenzofurans with contiguous tetra- and trisubstituted carbon centers in up to 96% enantiomeric excess (ee).
摘要
已开发出短寿命的C-O轴手性烯醇盐的对映选择性分子内共轭加成反应。反应以构型翻转的方式进行，并提供具有连续四取代和三取代碳中心的二氢苯并呋喃，对映体过量（ee）高达96%。
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