Liu Zen, Vunjak-Novakovic Gordana
Department of Biomedical Engineering, Columbia University in the City of New York.
Department of Biomedical Engineering, Columbia University in the City of New York; Department of Medicine, Columbia University in the City of New York.
Curr Opin Chem Eng. 2016 Feb;11:94-105. doi: 10.1016/j.coche.2016.01.012.
The dominant roles of the tumor microenvironment in regulating tumor formation, progression, and metastasis have driven the application of tissue engineering strategies in cancer biology. Highly dynamic and reciprocal communication of tumor cells with their surroundings suggests that studying cancer in custom-designed biomaterial scaffolds may lead to novel therapeutic targets and therapeutic regimens more reliably than traditional monolayer tissue culture models. As tissue engineering becomes progressively more successful in recapitulating the native tumor environment, critical insights into mechanisms of tumor resistance may be elucidated, to impact clinical practice, drug development, and biological research. We review here the recent developments in the use of custom-designed biomaterial scaffolds for modeling human tumors.
肿瘤微环境在调节肿瘤形成、进展和转移方面的主导作用推动了组织工程策略在癌症生物学中的应用。肿瘤细胞与其周围环境之间高度动态且相互的交流表明，在定制设计的生物材料支架中研究癌症可能比传统的单层组织培养模型更可靠地产生新的治疗靶点和治疗方案。随着组织工程在重现天然肿瘤环境方面越来越成功，可能会阐明对肿瘤耐药机制的关键见解，从而影响临床实践、药物开发和生物学研究。我们在此回顾了使用定制设计的生物材料支架来模拟人类肿瘤的最新进展。
