Liu Xuemei, Wang Wenjuan, Wang Xinrong, Qu Qinglan, Hao Cuifang
Reproductive Medicine Center, Yantai Yuhuangding Hospital, Affiliated Hospital of Qingdao University, Yantai, Shandong, China.
Reproductive Medicine Center, Yantai Yuhuangding Hospital, Affiliated Hospital of Qingdao University, Yantai, Shandong, China.
Eur J Obstet Gynecol Reprod Biol. 2016 Jul;202:9-13. doi: 10.1016/j.ejogrb.2016.04.028. Epub 2016 Apr 30.
To evaluate the effect of DHEA supplementation on in vitro fertilization (IVF) parameters and pregnancy outcomes in patients older than 37 years with normal ovarian reserve.
A retrospective cohort study was conducted to evaluate the impact of DHEA supplementation on IVF outcome of infertile women over 37 years with normal ovarian reserve between January 2012 and July 2014. 243 patients (study group) received 75mg of DHEA daily (25mg three times daily) before the IVF cycle. Another 243 patients (control group) received infertility treatment, but did not receive DHEA. The IVF outcome parameters in each group were compared.
Both groups did not show statistically significant differences in terms of patient demographics characteristics, mean numbers of oocytes retrieved and mature oocytes rate. While patients in the DHEA group have the significantly higher implantation rate and live birth rate compared with controls (30.13% versus 22.70%, 43.33% versus 28.26%). We also found that the cycle cancellation rate and miscarriage rate were lower in the DHEA group (1.23% versus 5.34%, 13.33% versus 28.89%).
DHEA supplementation may significantly improve IVF outcomes in infertile women over the age of 37.
评估补充脱氢表雄酮（DHEA）对卵巢储备功能正常的37岁以上患者体外受精（IVF）参数及妊娠结局的影响。
进行一项回顾性队列研究，以评估2012年1月至2014年7月期间补充DHEA对卵巢储备功能正常的37岁以上不孕女性IVF结局的影响。243例患者（研究组）在IVF周期前每天服用75mg DHEA（每日三次，每次25mg）。另外243例患者（对照组）接受不孕治疗，但未服用DHEA。比较两组的IVF结局参数。
两组在患者人口统计学特征、平均取卵数和成熟卵母细胞率方面均未显示出统计学上的显著差异。与对照组相比，DHEA组患者的着床率和活产率显著更高（分别为30.13%对22.70%，43.33%对28.26%）。我们还发现DHEA组的周期取消率和流产率较低（分别为1.23%对5.34%，13.33%对28.89%）。
补充DHEA可能显著改善37岁以上不孕女性的IVF结局。
