Jaja S I, Ogungbemi S O, Kehinde M O, Anigbogu C N
Department of Physiology, College of Medicine, University of Lagos, P.M.B. 12003, Lagos, Nigeria.
Department of Physiology, College of Medicine, University of Lagos, P.M.B. 12003, Lagos, Nigeria.
Pathophysiology. 2016 Jun;23(2):81-5. doi: 10.1016/j.pathophys.2016.04.004. Epub 2016 Apr 27.
The effect of l-arginine on liver function in SCD has received little or no attention. The effect of a chronic, oral, low-dose supplementation with l-arginine (1gm/day for 6 weeks) on some liver enzymes, lipid peroxidation and nitric oxide metabolites was studied in 20 normal (non-sickle cell anaemia; NSCA) subjects and 20 sickle cell anaemia (SCA) subjects. Ten milliliters of blood was withdrawn from an ante-cubital vein for the estimation of plasma arginine concentration ([R]), alanine aminotransaminase (ALT), aspartate aminotransaminase (AST) and alkaline phosphatase (ALP), plasma total bilirubin concentration [TB], malondialdehyde concentration [MDA] and nitric oxide metabolites concentration [NOx]. Before supplementation, ALT, AST, ALP (p<0.05 respectively) and TB (p<0.001) were higher in SCA subjects than in NSCA subjects. [R] and [NOx] were higher in NSCA subjects (p<0.001 and p<0.05 respectively). Supplementation caused greater percent increases in [R], and [NOX] in SCA than in NSCA subjects (p<0.001 in each case). l-Arginine caused greater percent reductions in ALT and AST in SCA subjects but greater percent reduction in ALP in NSCA subjects (p<0.001 in each case). Changes in [MDA] and [TB] in the two groups were similar. Study shows that chronic, oral, low-dose supplementation with l-arginine improved liver function, oxidative stress, plasma arginine concentration and nitric oxide metabolites levels in NSCA and SCA subjects. Responses in SCA subjects to l-arginine were more sensitive than in NSCA subjects.
L-精氨酸对镰状细胞病（SCD）肝功能的影响很少或几乎没有受到关注。本研究在20名正常（非镰状细胞贫血；NSCA）受试者和20名镰状细胞贫血（SCA）受试者中，探讨了长期口服低剂量L-精氨酸（1克/天，持续6周）对某些肝酶、脂质过氧化和一氧化氮代谢产物的影响。从前臂肘前静脉抽取10毫升血液，用于测定血浆精氨酸浓度（[R]）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）和碱性磷酸酶（ALP）、血浆总胆红素浓度[TB]、丙二醛浓度[MDA]和一氧化氮代谢产物浓度[NOx]。补充前，SCA受试者的ALT、AST、ALP（分别为p<0.05）和TB（p<0.001）高于NSCA受试者。NSCA受试者的[R]和[NOx]较高（分别为p<0.001和p<0.05）。与NSCA受试者相比，补充L-精氨酸后，SCA受试者的[R]和[NOX]百分比增加更大（每种情况均为p<0.001）。L-精氨酸使SCA受试者的ALT和AST百分比降低更大，但使NSCA受试者的ALP百分比降低更大（每种情况均为p<0.001）。两组中[MDA]和[TB]的变化相似。研究表明，长期口服低剂量L-精氨酸可改善NSCA和SCA受试者的肝功能、氧化应激、血浆精氨酸浓度和一氧化氮代谢产物水平。SCA受试者对L-精氨酸的反应比NSCA受试者更敏感。
