Kaya Serap, Gumus Mahmut, Gurbuz Yesim, Cabuk Devrim, Acikgoz Ozgur, Temiz Suleyman, Uygun Kazim
Department of Medical Oncology, Medical Faculty, Kocaeli University Kocaeli, Turkey.
Department of Medical Oncology, Medical Faculty, Bezmialem University Istanbul, Turkey.
Am J Transl Res. 2016 Feb 15;8(2):1228-36. eCollection 2016.
The aim of this study is to evaluate the prognostic value of β-catenin and LEF-1 expression in patients with operable gastric cancer that receive adjuvant treatment and the relationship between demographic and histopathological variables.
In this study, 82 gastric cancer patients treated with adjuvant treatment after surgery and followed in the Medical Oncology Department of Kocaeli University were included. β-catenin and LEF-1 expression were examined by immunuhistochemical analysis in paraffin embedded tumor tissues of the patients.
Median age was 56 (26-81) and follow up was 19 months (4-61). Performance status (ECOG) were 0-1 in all patients. Male/female ratio was 53/29 (64.6/35.4%). The median disease free survival (DFS) time was 17 months (SE: 3 95% CI: 11-23) and 3 years DFS rate was 39.7%. The median overall survival (OS) time was 28 months (SE: 4 95% CI: 20-36) and 3 years OS rate was 41.2%. There was no statistical correlation between β-catenin and LEF-1 expression and age, gender, performance status, tumor localization, T and N stage, lymphovascular, perinoral invasion, grade and operation type (>0.005). According to univariate analysis, we did not find significant effect of age, gender, T stage, lymphovascular, perinoral invasion, grade and operation type on overall survival (p>0.005). Good performance status (ECOG 0), tumor infiltration without diffuse type like linitis plastica, and lower N stage had positive effect on survival respectively (p=0.04, 0.033 and 0.005).
In this study group, we found that only N stage was an independent prognostic factor (<0.005). Demographic features of the patients, histopathological characteristics other than N stage, β-catenin and LEF-1 prognostic effects have not been shown.
本研究旨在评估接受辅助治疗的可手术胃癌患者中β-连环蛋白和LEF-1表达的预后价值以及人口统计学和组织病理学变量之间的关系。
本研究纳入了82例在科贾埃利大学医学肿瘤学系接受手术后辅助治疗并进行随访的胃癌患者。通过免疫组织化学分析检测患者石蜡包埋肿瘤组织中的β-连环蛋白和LEF-1表达。
中位年龄为56岁（26 - 81岁），随访时间为19个月（4 - 61个月）。所有患者的体能状态（ECOG）为0 - 1。男女比例为53/29（64.6/35.4%）。中位无病生存期（DFS）为17个月（标准误：3，95%置信区间：11 - 23），3年DFS率为39.7%。中位总生存期（OS）为28个月（标准误：4，95%置信区间：20 - 36），3年OS率为41.2%。β-连环蛋白和LEF-1表达与年龄、性别、体能状态、肿瘤定位、T和N分期、淋巴管、围口侵犯、分级及手术类型之间无统计学相关性（>0.005）。根据单因素分析，我们未发现年龄、性别、T分期、淋巴管、围口侵犯、分级及手术类型对总生存期有显著影响（p>0.005）。良好的体能状态（ECOG 0）、无弥漫型如皮革胃样的肿瘤浸润以及较低的N分期分别对生存有积极影响（p = 0.04、0.033和0.005）。
在该研究组中，我们发现只有N分期是独立的预后因素（<0.005）。患者的人口统计学特征、N分期以外的组织病理学特征、β-连环蛋白和LEF-1的预后作用均未显示。
