Revel D, Ogan M, Paajanen H, Grodd W, Couet W, Rosenau W, Brasch R C
Hôpital Cardio-Vasculaire et Pneumologique, Service de Radiologie, Lyon Montchat.
J Radiol. 1989 Feb;70(2):115-21.
MRI has been shown as an adapted non-invasive modality for the detection of tumours in humans. The development of paramagnetic contrast agents could add to the MRI diagnosis. With an experimental model of human breast (MX-1) carcinoma developed in nude mice, two different classes of contrast medium were tested. The first class includes the well-known Gd-DTPA and a new nitroxide compound on going development, representing non specific contrast agents. The specific contrast agents are represented by a metalloporphyrin Mn-TPPS4. Non specific contrast agents can add to the differentiation between well vascularized viable tissue and necrotic areas of tumors. While specific contrast agents may specifically target tumorous tissue.
