钆喷酸葡胺增强兔肾VX-2癌在T1加权磁共振图像上的表现
Gadolinium-DTPA enhancement of VX-2 carcinoma of the rabbit kidney on T1 weighted magnetic resonance images.
作者信息
Yancey J M, Ackerman N, Kaude J V, Googe R E, Fitzsimmons J R, Scott K N, Mancuso A A, Hackett R L, Hager D A, Caballero S
机构信息
Department of Radiology, College of Medicine, University of Florida, Gainesville 32610.
出版信息
Acta Radiol. 1987 Jul-Aug;28(4):479-82.
Experimental renal carcinoma was induced by percutaneous injection of VX-2 carcinoma cells into the left kidney in New Zealand white rabbits. Magnetic resonance imaging (MRI) was performed at 0.15 T before and after intravenous injection of 0.3 mmol gadolinium-DTPA (Gd-DTPA) per kg body weight. Gd-DTPA enhanced the tumors by increasing the signal intensity on T1 weighted images. The enhancement was evident immediately after Gd-DTPA injection, increasing during the observation time of 30 minutes. Histologically the areas of enhancement corresponded well to the viable tumor tissue.
通过经皮将VX-2癌细胞注射到新西兰白兔的左肾中来诱发实验性肾癌。在静脉注射每千克体重0.3毫摩尔钆-二乙三胺五乙酸（Gd-DTPA）之前和之后，于0.15特斯拉进行磁共振成像（MRI）。Gd-DTPA通过增加T1加权图像上的信号强度来增强肿瘤。注射Gd-DTPA后立即出现明显增强，在30分钟的观察期内持续增加。组织学上，增强区域与存活的肿瘤组织非常吻合。
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