Revel D, Brasch R C, Paajanen H, Rosenau W, Grodd W, Engelstad B, Fox P, Winkelhake J
Radiology. 1986 Feb;158(2):319-23. doi: 10.1148/radiology.158.2.2417274.
Gadolinium-DTPA (Gd-DTPA) enhancement of magnetic resonance (MR) imaging was tested for diagnostic utility in evaluating carcinoma. Human breast carcinoma implanted in ten nude mice was studied before and after injection of Gd-DTPA at two different doses (0.2 and 0.5 mmol/kg body weight). Before injection, all tumors appeared homogeneous in intensity on spin-echo images; after injection, it was possible to distinguish areas of strong enhancement from areas of weak enhancement. Histologic correlations showed that the strongly enhanced areas corresponded to richly vascularized connective tissue and apparently viable tumoral tissues, while the weakly enhanced areas corresponded to nonvascularized necrotic tissue. The results indicate that intravenously administered paramagnetic agents such as Gd-DTPA may improve the specificity and diagnostic accuracy of MR imaging by permitting better differentiation of tumor elements.
钆喷酸葡胺（Gd-DTPA）增强磁共振（MR）成像在评估癌症方面的诊断效用进行了测试。对十只裸鼠体内植入的人乳腺癌在注射两种不同剂量（0.2和0.5 mmol/kg体重）的Gd-DTPA前后进行了研究。注射前，所有肿瘤在自旋回波图像上强度均一；注射后，可以区分强化明显的区域和强化较弱的区域。组织学相关性显示，强化明显的区域对应血管丰富的结缔组织和明显存活的肿瘤组织，而强化较弱的区域对应无血管的坏死组织。结果表明，静脉注射钆等顺磁性剂如Gd-DTPA，通过更好地区分肿瘤成分，可能提高MR成像的特异性和诊断准确性。
