Selby C D, Toghill P J
Department of Medicine, University Hospital, Nottingham.
J R Soc Med. 1989 Apr;82(4):206-9. doi: 10.1177/014107688908200408.
Five splenectomized patients suffered six episodes of bacterial meningitis with positive cerebrospinal fluid cultures. They were admitted to the Nottingham hospitals between 1974 and 1985. The infecting organism in all cases was Streptococcus pneumoniae. Only one patient, who survived, had had pneumococcal vaccine; two patients died in spite of intensive therapy. There is now good evidence for giving prophylactic penicillin to asplenic patients but the efficacy of the pneumococcal vaccine remains uncertain.
5例脾切除患者发生了6次细菌性脑膜炎,脑脊液培养呈阳性。他们于1974年至1985年间入住诺丁汉的医院。所有病例的感染病原体均为肺炎链球菌。只有1例存活患者接种过肺炎球菌疫苗;2例患者尽管接受了强化治疗仍死亡。现在有充分证据表明应给无脾患者预防性使用青霉素,但肺炎球菌疫苗的疗效仍不确定。