Diabetes Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands; Department of Pathology and Laboratory Medicine, Child and Family Research Institute, The University of British Columbia, Vancouver, Canada.
Department of Pathology and Laboratory Medicine, Child and Family Research Institute, The University of British Columbia, Vancouver, Canada; Department of Surgery, Child and Family Research Institute, The University of British Columbia, Vancouver, Canada.
Trends Endocrinol Metab. 2016 Jul;27(7):442-445. doi: 10.1016/j.tem.2016.04.009. Epub 2016 May 6.
Glucagon-like peptide (GLP)-1 receptor agonists enhance insulin secretion and may improve pancreatic islet cell function. However, GLP-1 receptor (GLP-1R) agonist treatment may have more complex, and sometimes deleterious, effects on beta cells. We discuss the concepts of beta cell protection versus exhaustion for different GLP-1R agonists based on recent data.
胰高血糖素样肽-1（GLP-1）受体激动剂可增强胰岛素分泌，并可能改善胰岛细胞功能。然而，GLP-1 受体（GLP-1R）激动剂治疗对β细胞可能具有更复杂的、有时是有害的影响。我们根据最近的数据讨论了不同 GLP-1R 激动剂的β细胞保护与衰竭概念。
