接受冷冻治疗的早产儿视网膜病变患儿的晚期临床特征。

Late clinical characteristics of infants with retinopathy of prematurity and treated with cryotherapy.

作者信息

Cerman Eren, Ozarslan Ozcan Deniz, Celiker Hande, Eraslan Muhsin, Sahin Ozlem, Kazokoglu Haluk

机构信息

Department of Ophthalmology, Marmara University School of Medicine, Istanbul 34890, Turkey.

Department of Ophthalmology, Akcakale State Hospital, Sanliurfa 63500, Turkey.

出版信息

Int J Ophthalmol. 2016 Apr 18;9(4):567-71. doi: 10.18240/ijo.2016.04.15. eCollection 2016.

DOI:10.18240/ijo.2016.04.15

PMID:27162730

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4853353/

Abstract

AIM

To describe the clinical characteristics and late results of patients with retinopathy of prematurity (ROP) treated with "6h cryotherapy".

METHODS

Out of 1252 infants screened for ROP, 52 patients were treated with temporal 6h cryotherapy from 1997 to 2005 were recalled to our clinic. Among these 23 patients were available and 46 eyes of 23 infants were included to evaluate for visual acuity, refractive error, ocular alignment, nystagmus, retinal examination (abnormal branching of retinal vessels, retinal thinning, latis degenerations, tortuosity of vessels, straightening of temporal vessels, narrowing of the angle of vessel in the juxtapapillary entrance, pigment changes, macular heterotopia), optic atrophy and optic disc cupping, axial length at birth and axial length at 1y.

RESULTS

The median age at examination was 7 (5-18)y. In 32.6% of patients, the visual acuity was ≤20/200 and the mean best corrected visual acuity was 20/35 as measured with a Snellen chart. Mean spherical refractive error was -1.76±2.69 D. The degree of myopia at the last examination was found to be correlated with the elongation of the eye in the first year of life. Exotropia was present in 17.4% (n=8) of infants and esotropia in 13% (n=6). The most common retinal abnormality was abnormal branching of retinal vessels (82.6%) followed by retinal thinning (52.2%).

CONCLUSION

The late clinical outcomes of infants with ROP treated in our clinic with cryotherapy seems to comparable with results of laser treatment.

摘要

目的

描述接受“6小时冷冻疗法”治疗的早产儿视网膜病变（ROP）患者的临床特征和远期疗效。

方法

在1252例接受ROP筛查的婴儿中，回顾性分析1997年至2005年期间接受颞侧6小时冷冻疗法治疗的52例患者。其中23例患者可供研究，纳入23例婴儿的46只眼，评估其视力、屈光不正、眼位、眼球震颤、视网膜检查（视网膜血管分支异常、视网膜变薄、视网膜色素变性、血管迂曲、颞侧血管变直、视乳头旁入口处血管夹角变窄、色素改变、黄斑异位）、视神经萎缩和视盘杯状凹陷、出生时眼轴长度和1岁时眼轴长度。

结果

检查时的中位年龄为7（5 - 18）岁。32.6%的患者视力≤20/200，用斯内伦视力表测量的平均最佳矫正视力为20/35。平均球镜屈光不正为-1.76±2.69D。发现最后一次检查时的近视程度与出生后第一年眼球的伸长有关。17.4%（n = 8）的婴儿存在外斜视，13%（n = 6）存在内斜视。最常见视网膜异常是视网膜血管分支异常（82.6%），其次是视网膜变薄（52.2%）。