Gursoy Huseyin, Basmak Hikmet, Bilgin Burak, Erol Nazmiye, Colak Ertugrul
Department of Ophthalmology, Eskişehir Osmangazi University Medical Faculty , Eskişehir , Turkey .
Strabismus. 2014 Jun;22(2):68-73. doi: 10.3109/09273972.2014.904899. Epub 2014 Apr 17.
To investigate the effects of mild-to-severe retinopathy of prematurity (ROP) on refractive state and the incidence of strabismus.
Infants born ≤32 weeks of gestation were prospectively evaluated. Inclusion criteria were a follow-up of at least 6 months and at least stage 1 ROP. Group 1 included stage 1 ROP cases. Cases with stage 2 or 3 ROP without indication for treatment formed the second group. Group 3 included cases who received treatment for ROP. Logistic regression, adjusted for birth weight and gestational age, and multiple comparison tests were used to compare outcomes among groups.
The mean follow-up time was 20.9 ± 6.6 months. In the first (n = 21), second (n = 22), and third groups (n = 23), the right spherical equivalents (SE) were 1.17 ± 1.33, -0.18 ± 3.09, and -1.08 ± 4.05 diopters, and the left SEs were 1.23 ± 1.34, -0.09 ± 3.24, and -1.46 ± 4.02 diopters, respectively (p = 0.026 for right SE and 0.008 for left SE). The incidences of anisometropia were 3/21, 4/22, and 11/23 in the first, second, and third groups, respectively (adjusted odds ratios [aOR] for group 3 vs 1 = 5.39, aOR for group 3 vs 2 = 4.06). Strabismus developed in 7/21, 6/22, and 10/23 in groups one, two, and three, respectively (aOR for group 3 vs 1 = 2.06, aOR for group 3 vs 2 = 2.27). Eighteen of these were esotropias.
Refractive errors and strabismus were associated with mild-to-severe ROP. Esotropia was the most frequent type of strabismus.
探讨轻度至重度早产儿视网膜病变（ROP）对屈光状态和斜视发生率的影响。
对孕周≤32周出生的婴儿进行前瞻性评估。纳入标准为至少随访6个月且ROP至少为1期。第1组包括1期ROP病例。2期或3期ROP且无治疗指征的病例组成第2组。第3组包括接受ROP治疗的病例。采用经出生体重和孕周校正的逻辑回归及多重比较检验来比较各组间的结果。
平均随访时间为20.9±6.6个月。在第1组（n = 21）、第2组（n = 22）和第3组（n = 23）中，右眼等效球镜度（SE）分别为1.17±1.33、-0.18±3.09和-1.08±4.05屈光度，左眼SE分别为1.23±1.34、-0.09±3.24和-1.46±�̀.02屈光度（右眼SE的p值为0.026，左眼SE的p值为0.008）。第1组、第2组和第3组的屈光参差发生率分别为3/21、4/2̀和11/23（第3组与第1组的校正比值比[aOR] = 5.39，第3组与第2组的aOR = 4.06）。第1组、第2组和第3组中分别有7/21、6/22和10/23发生斜视（第3组与第1组的aOR = 2.06，第3组与第2组的aOR = 2.27）。其中18例为内斜视。
屈光不正和斜视与轻度至重度ROP相关。内斜视是最常见的斜视类型。
