Qureshi Nilam, Chaudhari Ravindra, Mane Pramod, Shinde Manish, Jadakar Sandesh, Rane Sunit, Kale Bharat, Bhalerao Anand, Amalnerkar Dinesh
IEEE Trans Nanobioscience. 2016 Apr;15(3):258-64. doi: 10.1109/TNB.2016.2535285. Epub 2016 May 3.
In our contemporary endeavor, metallic molybdenum (Mo) and semiconducting molybdenum trioxide (MoO3) nanostructures have been simultaneously generated via solid state reaction between molybdenum (III) chloride (MoCl3) and polyphenylene sulfide (PPS) at 285 (°)C in unimolar ratio for different time durations, namely, 6 h, 24 h, and 48 h. The resultant nanocomposites (NCs) revealed formation of predominantly metallic Mo for all the samples. However, MoO3 gradually gained prominent position as secondary phase with rise in reaction time. The present study was intended to investigate the antibacterial potential of metal-metal oxide-polymer NCs, i.e., Mo- MoO3-PPS against microorganisms, viz., Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Aspergillus fumigatus. The antibacterial activity of the NCs was evaluated by agar well diffusion investigation. Maximum sensitivity concentrations of NCs were determined by finding out minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC). Moreover, the NCs prepared at reaction time of 48 h exhibited best MBC values and were tested with time kill assay which revealed that the growth of S. aureus was substantially inhibited by Mo- MoO3-PPS NCs. This synchronized formation of Mo- MoO3 nanostructures in an engineering thermoplastic may have potential antimicrobial applications in biomedical devices and components. Prima facie results on antifungal activity are indicative of the fact that these materials can show anti-cancer behavior.
在我们当前的研究中，通过氯化钼（III）（MoCl₃）与聚苯硫醚（PPS）在285℃以单摩尔比进行不同时长（即6小时、24小时和48小时）的固态反应，同时生成了金属钼（Mo）和半导体三氧化钼（MoO₃）纳米结构。所得的纳米复合材料（NCs）显示，所有样品中主要形成了金属Mo。然而，随着反应时间的增加，MoO₃作为第二相逐渐占据显著地位。本研究旨在探究金属 - 金属氧化物 - 聚合物纳米复合材料，即Mo - MoO₃ - PPS对微生物，如铜绿假单胞菌、金黄色葡萄球菌、肺炎克雷伯菌和烟曲霉的抗菌潜力。通过琼脂孔扩散法研究评估了纳米复合材料的抗菌活性。通过测定最低抑菌浓度（MIC）和最低杀菌/杀真菌浓度（MBC/MFC）来确定纳米复合材料的最大敏感浓度。此外，在48小时反应时间制备的纳米复合材料表现出最佳的MBC值，并通过时间杀灭试验进行了测试，结果表明Mo - MoO₃ - PPS纳米复合材料显著抑制了金黄色葡萄球菌的生长。在工程热塑性塑料中这种Mo - MoO₃纳米结构的同步形成可能在生物医学设备和部件中具有潜在的抗菌应用。关于抗真菌活性的初步结果表明这些材料可能具有抗癌行为。
