Cagnacci A, Melis G B, Soldani R, Gambacciani M, Paoletti A M, Fioretti P
Department of Obstetrics and Gynecology, University of Pisa, Italy.
Life Sci. 1989;44(19):1395-402. doi: 10.1016/0024-3205(89)90397-4.
The role exerted by the endogenous opioid system on thermoregulation has been studied in nine postmenopausal women before and after the chronic administration of the dopamine agonist bromocriptine (5 mg/day). These women randomly received an infusion of the opioid antagonist naloxone (1.6 mg/h for 4 h) or saline on two consecutive days, before and after 30 days of bromocriptine administration. Body temperature as evaluated by rectal temperature, did not vary during saline infusion performed both before and after 30 days of bromocriptine administration. In untreated women naloxone infusion significantly reduced body core temperature. The hypothermic response to naloxone was significantly greater following chronic bromocriptine administration. These results indicate that bromocriptine seems to increase the activity of the endogenous opioid system on the mechanisms which regulate body temperature in postmenopausal women.
内源性阿片系统对体温调节的作用已在9名绝经后女性中进行了研究，这些女性在长期服用多巴胺激动剂溴隐亭（5毫克/天）前后接受了相关研究。这些女性在服用溴隐亭30天前后，连续两天随机接受阿片拮抗剂纳洛酮输注（1.6毫克/小时，持续4小时）或生理盐水输注。通过直肠温度评估的体温，在服用溴隐亭30天前后进行的生理盐水输注过程中均未发生变化。在未治疗的女性中，纳洛酮输注显著降低了体核温度。长期服用溴隐亭后，对纳洛酮的低温反应显著增强。这些结果表明，溴隐亭似乎增强了内源性阿片系统对绝经后女性体温调节机制的作用。
