Cagnacci A, Melis G B, Paoletti A M, Soldani R, Fioretti P
Department of Obstetrics and Gynecology, University of Pisa, Italy.
Life Sci. 1988;42(5):547-53. doi: 10.1016/0024-3205(88)90096-3.
The influence of endogenous opioid peptides on body thermoregulation has been studied in untreated postmenopausal women and in the same subjects after chronic administration of the antidopaminergic drug veralipride (200 mg/day for 20 days). Subjects randomly received an infusion of the opioid antagonist naloxone (1.6 mg/h for 4 h) or saline on two consecutive days, both before and after veralipride treatment. In untreated subjects body core temperature, as evaluated by rectal temperature, did not vary during saline infusion, whereas a significant decrease was observed during naloxone infusion. Chronic administration of veralipride significantly increased the hypothermic response to naloxone. Therefore, veralipride seems to increase the activity of endogenous opioid peptides on mechanisms which regulate body temperature in postmenopausal women.
内源性阿片肽对体温调节的影响已在未经治疗的绝经后女性以及在长期服用抗多巴胺能药物维拉必利（200毫克/天，持续20天）后的同一受试者中进行了研究。受试者在维拉必利治疗前后连续两天随机接受阿片类拮抗剂纳洛酮（1.6毫克/小时，持续4小时）或生理盐水输注。在未经治疗的受试者中，通过直肠温度评估的体核温度在输注生理盐水期间没有变化，而在输注纳洛酮期间观察到显著下降。长期服用维拉必利显著增加了对纳洛酮的低温反应。因此，维拉必利似乎增强了内源性阿片肽对绝经后女性体温调节机制的作用。
