空肠和回肠胃肠道间质瘤的临床病理特征及预后

Clinicopathological Features and Prognosis of Gastrointestinal Stromal Tumor Located in the Jejunum and Ileum.

作者信息

Feng Fan, Wang Fei, Wang Qiao, Zheng Gaozan, Xu Guanghui, Liu Shushang, Liu Zhen, Guo Man, Lian Xiao, Zhang Hongwei

机构信息

Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

Department of General Surgery, No. 534 Hospital of PLA, Luoyang, China.

出版信息

Dig Surg. 2019;36(2):153-157. doi: 10.1159/000487147. Epub 2018 Apr 26.

DOI:10.1159/000487147

PMID:29698938

Abstract

BACKGROUND

Data about the clinicopathological features and prognosis of gastrointestinal stromal tumors (GISTs) located in jejunum and ileum are lacking. The present study aims to investigate the features and prognosis of jejunal and ileal GISTs based on the Surveillance, Epidemiology, and End Results (SEER) database.

PATIENTS AND METHODS

Cases of jejunal and ileal GISTs were extracted from SEER database. Clinicopathological characteristics and survival data of patients were recorded. The clinicopathological features and prognosis of patients were analyzed.

RESULTS

There were 399 male (56.8%) and 303 female (43.2%). The median age was 60 years (17-96). Four hundred and seventy-two tumors were located in the jejunum (67.2%) and 230 tumors in the ileum (32.8%). The median tumor size was 7.0 cm (0.5-90). The 5-, 10-, and 20-year disease specific survival (DSS) was 84.4, 71.2, and 54.2% respectively. Clinicopathological features were comparable between tumors located in the jejunum and ileum (all p > 0.05) except gender and tumor size (both p < 0.05). Jejunal GISTs, rather than ileal GISTs (p = 0.043), were commonly found in the males. The tumor size of jejunal GISTs was smaller than that of ileal GISTs (p = 0.010). The DSS of jejunal GISTs was comparable to that of ileal GISTs (p = 0.269).

CONCLUSIONS

Jejunal GISTs were more common than ileal GISTs. The prognosis was comparable between jejunal and ileal GISTs.

摘要

背景

关于空肠和回肠胃肠道间质瘤（GIST）的临床病理特征及预后的数据尚缺。本研究旨在基于监测、流行病学和最终结果（SEER）数据库调查空肠和回肠GIST的特征及预后。

患者与方法

从SEER数据库中提取空肠和回肠GIST病例。记录患者的临床病理特征及生存数据。分析患者的临床病理特征及预后。

结果

男性399例（56.8%），女性303例（43.2%）。中位年龄为60岁（17 - 96岁）。472例肿瘤位于空肠（67.2%），230例肿瘤位于回肠（32.8%）。中位肿瘤大小为7.0 cm（0.5 - 90）。5年、10年和20年疾病特异性生存率（DSS）分别为84.4%、71.2%和54.2%。除性别和肿瘤大小外（均p < 0.05），空肠和回肠肿瘤的临床病理特征具有可比性（所有p > 0.05）。空肠GIST常见于男性，而非回肠GIST（p = 0.043）。空肠GIST的肿瘤大小小于回肠GIST（p = 0.010）。空肠GIST的DSS与回肠GIST相当（p = 0.269）。