Yu Junhong, Rawtaer Iris, Mahendran Rathi, Kua Ee-Heok, Feng Lei
a Department of Psychological Medicine , National University Hospital , Singapore.
b Department of Psychological Medicine, Yong Loo Lin School of Medicine , National University of Singapore , Singapore.
Laterality. 2017 May;22(3):268-278. doi: 10.1080/1357650X.2016.1184677. Epub 2016 May 11.
Despite the abundance of studies on asymmetries in manual laterality, a marker for atypical brain lateralization in depression and anxiety, findings in this area are mixed. Traditionally, research have looked at individual differences in depression and anxiety as a function of the direction of asymmetry. However, recent research has emphasized on studying the degree of asymmetry in addition to its direction. To these ends, the present study aims to unravel the associations between the degree and direction of manual lateralization, and depression/anxiety. Cognitively healthy elderlies (N = 326, 91 males, M = 68) were administered grip strength assessments on both hands and self-report measures of depression and anxiety. Partial correlation analyses controlling for age, education and sex revealed significant positive associations between degree of lateralization and anxiety in the overall sample and among right-dominant participants, as well as a significant positive relationship between degree of lateralization and depression among right-dominant participants. None of the correlations involving the direction of lateralization yielded significance, neither was there significant differences between left- and right-dominant participants on depression and anxiety scores. These findings suggest that the degree of manual lateralization, but not direction, is related to depression and anxiety at least among right-dominant individuals.
尽管关于手部偏侧性不对称的研究很多，而这种不对称是抑郁和焦虑中非典型大脑偏侧化的一个标志，但该领域的研究结果却参差不齐。传统上，研究将抑郁和焦虑中的个体差异视为不对称方向的函数。然而，最近的研究除了强调研究不对称方向外，还注重研究不对称程度。为此，本研究旨在揭示手部偏侧化的程度和方向与抑郁/焦虑之间的关联。对认知健康的老年人（N = 326，91名男性，平均年龄68岁）进行了双手握力评估以及抑郁和焦虑的自我报告测量。控制年龄、教育程度和性别的偏相关分析显示，在整个样本以及右利手参与者中，偏侧化程度与焦虑之间存在显著正相关，在右利手参与者中，偏侧化程度与抑郁之间也存在显著正相关。涉及偏侧化方向的相关性均无显著性，左利手和右利手参与者在抑郁和焦虑得分上也没有显著差异。这些发现表明，至少在右利手个体中，手部偏侧化程度而非方向与抑郁和焦虑有关。
