Zheng Jiaojiao, Li Chen, Lu Weihui, Wang Cong, Ai Zhilong
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Department of General Surgery, Zhongshan Hospital (Qingpu Branch), Fudan University, Shanghai 201700, P.R. China.
Oncotarget. 2016 Jun 7;7(23):34918-29. doi: 10.18632/oncotarget.9201.
Thyroid stimulating hormone (TSH) is the major growth factor for thyrocytes, but the pathogenic role of serum TSH in thyroid cancer (TC) is unknown. The association between TSH level and the development of thyroid cancer has been widely evaluated recently. However, the results remain conflicting. To develop an understanding of the relationship between TSH exposure and thyroid cancer, a meta-analysis of 56 studies involving 20227 thyroid cancer cases and 50003 controls with benign thyroid nodule was performed. Overall, significantly increased TSH level was observed in thyroid cancer patients compared with controls (RoM: 1.44, 95% CI: 1.32-1.56, P < 10-5). The pooled analyses also revealed that higher serum TSH level were significantly associated with the size of TC nodule and malignancy as well as lymph node metastasis. Furthermore, significantly increased THS levels were observed preferentially for papillary thyroid cancer when stratified by histological type of tumors. However, the diagnostic value of TSH level for TC might be limited. These results suggest that higher serum TSH concentration is associated with an increased risk of thyroid cancer.
促甲状腺激素（TSH）是甲状腺细胞的主要生长因子，但血清TSH在甲状腺癌（TC）中的致病作用尚不清楚。TSH水平与甲状腺癌发生之间的关联最近已得到广泛评估。然而，结果仍相互矛盾。为了深入了解TSH暴露与甲状腺癌之间的关系，我们对56项研究进行了荟萃分析，这些研究涉及20227例甲状腺癌病例和50003例患有良性甲状腺结节的对照。总体而言，与对照组相比，甲状腺癌患者的TSH水平显著升高（比值比：1.44，95%置信区间：1.32 - 1.56，P < 10⁻⁵）。汇总分析还显示，较高的血清TSH水平与TC结节大小、恶性程度以及淋巴结转移显著相关。此外，按肿瘤组织学类型分层时，甲状腺乳头状癌患者的TSH水平优先显著升高。然而，TSH水平对TC的诊断价值可能有限。这些结果表明，较高的血清TSH浓度与甲状腺癌风险增加相关。
