Ferre Navarrete F, Pérez Páramo M, Fermin Ordoño J, López Gómez V
a Servicio Psiquiatría B ., Hospital General Universitario Gregorio Marañón , Madrid , Spain.
b Medical Unit, Pfizer GEP, S. L. U ., Madrid , Spain.
Behav Sleep Med. 2017 Nov-Dec;15(6):491-501. doi: 10.1080/15402002.2016.1163703. Epub 2016 May 11.
Sleep disturbance is one of the key diagnostic criteria for generalized anxiety disorder (GAD). In this cross-sectional, prospective, observational, and multicenter study, factors associated with the prevalence of insomnia and the impact of insomnia-associated factors on quality of life were evaluated. Using multivariate analyses, the factor most strongly associated with the presence of insomnia (ISI ≥ 8) was the severity of the disorder (Odds Ratio [OR]: 9.253 for severe GAD; 95% Confidence Interval [CI]: 1.914-44.730; p = 0.006), pain interference and symptoms of depression (OR: 1.018; 95% CI 1.003-1.033; p = 0.016 and OR: 1.059; 95% CI 1.019-1.101; p = 0.004, respectively). Insomnia was not related to quality of life. Our results show insomnia to be a common health condition among patients with GAD, associated with the severity of anxiety and depressive symptoms and pain interference.
睡眠障碍是广泛性焦虑症（GAD）的关键诊断标准之一。在这项横断面、前瞻性、观察性多中心研究中，评估了与失眠患病率相关的因素以及失眠相关因素对生活质量的影响。通过多变量分析，与失眠（失眠严重程度指数[ISI]≥8）最密切相关的因素是疾病的严重程度（严重广泛性焦虑症的优势比[OR]：9.253；95%置信区间[CI]：1.914 - 44.730；p = 0.006）、疼痛干扰和抑郁症状（OR分别为：1.018；95% CI 1.003 - 1.033；p = 0.016和OR：1.059；95% CI 1.019 - 1.101；p = 0.004）。失眠与生活质量无关。我们的研究结果表明，失眠在广泛性焦虑症患者中是一种常见的健康状况，与焦虑和抑郁症状的严重程度以及疼痛干扰有关。
