Wheelock K M, Fufaa G D, Nelson R G, Hanson R L, Knowler W C, Sinha M
Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.
Pediatr Obes. 2017 Aug;12(4):295-303. doi: 10.1111/ijpo.12142. Epub 2016 May 12.
Childhood obesity is associated with increased cardiometabolic risk.
To study the relationship between body mass index (BMI) and cardiometabolic risk factors in American Indian children and adolescents.
Differences in metabolic variables by age and sex-specific BMI percentiles (2000 Centers for Disease Control and Prevention Growth Charts) were examined in a cross-sectional analysis of 2977 individuals across three age categories. Children with an exam in two consecutive age categories were included in a longitudinal analysis. Spearman's correlations were used to test the association of BMI percentile with anthropometric and biochemical variables.
Body mass index percentile correlated with systolic (r = 0.24 to 0.38) and diastolic (r = 0.13 to 0.22) blood pressure, fasting plasma glucose (r = 0.20 to 0.33), 2-h plasma glucose (r = 0.30 to 0.46), total cholesterol (r = 0.12 to 0.23), serum triglycerides (r = 0.40 to 0.51) and HDL cholesterol (r = -0.36 to -0.43) in each age group (5-9, 10-13 and 14-17 years). Among participants examined in multiple age categories, BMI percentile increased over time. Change in BMI percentile from one age category to the next was associated with an increase in fasting glucose, 2-h glucose and triglycerides and a decrease in HDL cholesterol.
Higher BMI was associated with blood pressure elevation, hyperglycaemia and dyslipidaemia in American Indian children and adolescents.
儿童肥胖与心血管代谢风险增加相关。
研究美国印第安儿童和青少年体重指数（BMI）与心血管代谢风险因素之间的关系。
在对三个年龄组的2977名个体进行的横断面分析中，根据年龄和性别特异性BMI百分位数（2000年疾病控制和预防中心生长图表）检查代谢变量的差异。连续两个年龄组接受检查的儿童纳入纵向分析。采用Spearman相关性分析来检验BMI百分位数与人体测量和生化变量之间的关联。
在每个年龄组（5 - 9岁、10 - 13岁和14 - 17岁）中，BMI百分位数与收缩压（r = 0.24至0.38）和舒张压（r = 0.13至0.22）、空腹血糖（r = 0.20至0.33）、2小时血糖（r = 0.30至0.46）、总胆固醇（r = 0.12至0.23）、血清甘油三酯（r = 0.40至0.
