个人及家族病史在识别乙肝携带者方面的可靠性。

The reliability of personal and family medical histories in the identification of hepatitis B carriers.

作者信息

Comfort M B, Wu P C

机构信息

Department of Oral Surgery and Oral Medicine, Prince Philip Dental Hospital, Hong Kong.

出版信息

Oral Surg Oral Med Oral Pathol. 1989 May;67(5):531-4. doi: 10.1016/0030-4220(89)90268-5.

DOI:10.1016/0030-4220(89)90268-5

PMID:2717151

Abstract

Blood specimens were obtained from 300 patients and were tested for the five hepatitis B virus (HBV) serum markers: HBsAg, HbeAg, anti-HBs, anti-HBe and anti-HBc. Medical histories were checked to determine any previous experience of HBV infection in the patients or their families. Serum markers showed that 54.3% of the group had evidence of earlier HBV infection, 10% were HBsAg carriers, and 3% were HBeAg-positive. The patients' own histories correctly identified carriers in 23.1% of those giving a positive HBV history (p less than 0.05). Family histories were found to be an unreliable means of detecting HBV carriers. HBeAg carriers were twice as likely to be identified by their histories than HBsAg carriers. Blood donation refusal was the most frequent indicator of previous HBV infection.

摘要

从300名患者身上采集血样，检测乙肝病毒（HBV）的五项血清标志物：乙肝表面抗原（HBsAg）、乙肝e抗原（HBeAg）、乙肝表面抗体（抗-HBs）、乙肝e抗体（抗-HBe）和乙肝核心抗体（抗-HBc）。检查病史以确定患者本人或其家人既往是否有HBV感染史。血清标志物显示，该组中54.3%的人有既往HBV感染证据，10%为HBsAg携带者，3%为HBeAg阳性。患者本人的病史在自述有阳性HBV病史的人中正确识别出携带者的比例为23.1%（p<0.05）。发现家族病史是检测HBV携带者不可靠的方法。HBeAg携带者通过病史被识别出来的可能性是HBsAg携带者的两倍。献血拒绝是既往HBV感染最常见的指标。