Department of Radiation Oncology, University Hospital of Muenster, Muenster, Germany.
Oncol Res Treat. 2016;39(5):290-4. doi: 10.1159/000445864. Epub 2016 Apr 25.
With advances in modern diagnostic and therapeutic modalities, the main goal of intrathoracic radiation treatment is to reduce treatment-related toxicities. Here, we describe a series of cases that involved positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI)-based radiation therapy (RT) for the treatment of primary cardiac angiosarcoma (PCA).
The medical records of 3 patients who underwent image-guided RT at our department between 2012 and 2015 were analyzed.
3 patients with PCA underwent pre-therapeutic imaging with fluorodeoxyglucose (FDG)-PET/CT (n = 3), as well as PET/MRI (n = 2) or MRI alone (n = 1). 2 patients underwent primary tumor resection (cases 1 and 2). The tumor in case 3 was unresectable and the patient underwent definitive chemoradiation. Intensity-modulated RT was applied with a median RT dose of 50.4 Gy. At the end of the study, 2 of the patients had survived for 35 and 16 months post-treatment (cases 1 and 3, respectively), and no evidence of tumor progression has since been detected.
For the cases examined, RT was a feasible and tolerable treatment for PCA, and FDG-PET-MRI successfully characterized each PCA for therapy planning.
随着现代诊断和治疗方式的进步，胸内放射治疗的主要目标是降低治疗相关毒性。在这里，我们描述了一系列使用正电子发射断层扫描/计算机断层扫描（PET/CT）和磁共振成像（MRI）进行基于图像的放射治疗（RT）治疗原发性心脏血管肉瘤（PCA）的病例。
分析了 2012 年至 2015 年期间在我们科室接受图像引导 RT 的 3 名患者的病历。
3 名 PCA 患者接受了氟脱氧葡萄糖（FDG）-PET/CT（n = 3）以及 PET/MRI（n = 2）或单独 MRI（n = 1）的治疗前影像学检查。2 名患者接受了原发性肿瘤切除术（病例 1 和 2）。病例 3 的肿瘤无法切除，患者接受了根治性放化疗。采用调强 RT，中位 RT 剂量为 50.4 Gy。在研究结束时，2 名患者在治疗后分别存活了 35 个月和 16 个月（病例 1 和 3），此后未发现肿瘤进展的证据。
对于检查的病例，RT 是 PCA 的一种可行且可耐受的治疗方法，FDG-PET-MRI 成功地为每个 PCA 的治疗计划提供了特征。
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