Department of Radiation Oncology, University Hospital of Muenster, Muenster, Germany.
Department of Radiation Oncology, University Hospital of Muenster, Muenster, Germany.
Can J Cardiol. 2016 Jun;32(6):829.e7-829.e10. doi: 10.1016/j.cjca.2015.07.010. Epub 2015 Jul 17.
Radiotherapy (RT) for inoperable patients with primary cardiac sarcomas or residual tumor is often limited by the sensitivity of the heart and lung to radiation injury. We describe a novel treatment modality with adaptive radiotherapy (ART) using tumor volume tracking in a 37-year-old woman who presented with unresectable primary cardiac angiosarcoma. The patient was treated using positron emission tomography/magnetic resonance imaging-guided ART with 55.8 Gy concomitant with paclitaxel chemotherapy. In conclusion, the treatment was well tolerated, and a significant tumor volume reduction of ∼ 57% was achieved during radiotherapy, suggesting the effectiveness and tolerability of ART in combination with paclitaxel-based chemotherapy.
对于无法手术的原发性心脏肉瘤或残留肿瘤患者，放射治疗（RT）通常受到心脏和肺对放射损伤敏感性的限制。我们描述了一种新的治疗方式，即使用肿瘤体积跟踪的自适应放射治疗（ART），对一名 37 岁患有不可切除的原发性心脏血管肉瘤的女性进行治疗。该患者接受了正电子发射断层扫描/磁共振成像引导的 ART 治疗，同时联合紫杉醇化疗，剂量为 55.8 Gy。总之，该治疗方法耐受性良好，在放射治疗期间肿瘤体积显著缩小了约 57%，提示 ART 联合紫杉醇为基础的化疗具有有效性和耐受性。
