餐时胰岛素可降低1型糖尿病儿童的动脉僵硬度。
Premeal insulin decreases arterial stiffness in children with type 1 diabetes.
作者信息
Meehan Colette S, Kethireddy Pooja L, Ashcraft Jordan K, Shuster Jonathan J, Haller Michael J
机构信息
Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Department of Health Outcomes and Policy Biostatistics Epidemiology and Research Design, Clinical Translational Science Institute, University of Florida, Gainesville, FL 32610, USA.
出版信息
Pediatr Diabetes. 2017 Jun;18(4):311-314. doi: 10.1111/pedi.12389. Epub 2016 May 13.
OBJECTIVE
To determine the effects of omitting meal time insulin on arterial stiffness in children with type 1 diabetes.
RESEARCH DESIGN AND METHODS
In this prospective, randomized, crossover study, radial artery tonometry and augmentation index adjusted to heart rate 75 (AI ) were used to measure arterial stiffness. Children were randomized to receive or omit premeal insulin and completed the crossover portion of the study on a subsequent day. AI was determined when fasting, 1, and 2 h postmeal.
RESULTS
When comparing change in AI from baseline to 1 h and baseline to 2 h, when subjects received premeal insulin vs. no insulin, AI was 4.5 units lower at 1 h (p = 0.011, 95% CI:1.1 lower to 8 lower) and 4.3 units lower at 2 h (p = 0.062, 95% CI: 0.2 higher to 8.9 lower) (n = 40).
CONCLUSIONS
Arterial stiffness is decreased by premeal insulin in children with type 1 diabetes.
目的
确定省略餐时胰岛素对1型糖尿病儿童动脉僵硬度的影响。
研究设计与方法
在这项前瞻性、随机、交叉研究中，使用桡动脉张力测量法和根据心率75调整的增强指数（AI）来测量动脉僵硬度。儿童被随机分为接受或省略餐前胰岛素，并在随后一天完成研究的交叉部分。在空腹、餐后1小时和2小时测定AI。
结果
比较从基线到1小时以及从基线到2小时AI的变化，当受试者接受餐前胰岛素与不接受胰岛素时，1小时时AI低4.5个单位（p = 0.011，95%CI：低1.1至低8），2小时时低4.3个单位（p = 0.062，95%CI：高0.2至低8.9）（n = 40）。
结论
1型糖尿病儿童的餐前胰岛素可降低动脉僵硬度。
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