延缓心血管衰老的药理学策略
Pharmacological Strategies to Retard Cardiovascular Aging.
作者信息
Alfaras Irene, Di Germanio Clara, Bernier Michel, Csiszar Anna, Ungvari Zoltan, Lakatta Edward G, de Cabo Rafael
机构信息
From the Experimental Gerontology Section, Translational Gerontology Branch (I.A., C.D.G., M.B., R.d.C.) and Laboratory of Cardiovascular Science (E.G.L.), National Institute on Aging, National Institutes of Health, Baltimore, MD; Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy (C.D.G.); and Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK (A.C., Z.U.).
出版信息
Circ Res. 2016 May 13;118(10):1626-42. doi: 10.1161/CIRCRESAHA.116.307475.
Aging is the major risk factor for cardiovascular diseases, which are the leading cause of death in the United States. Traditionally, the effort to prevent cardiovascular disease has been focused on addressing the conventional risk factors, including hypertension, hyperglycemia, hypercholesterolemia, and high circulating levels of triglycerides. However, recent preclinical studies have identified new approaches to combat cardiovascular disease. Calorie restriction has been reproducibly shown to prolong lifespan in various experimental model animals. This has led to the development of calorie restriction mimetics and other pharmacological interventions capable to delay age-related diseases. In this review, we will address the mechanistic effects of aging per se on the cardiovascular system and focus on the prolongevity benefits of various therapeutic strategies that support cardiovascular health.
衰老 是心血管疾病的主要风险因素，而心血管疾病是美国的首要死因。传统上，预防心血管疾病的努力一直集中在应对传统风险因素上，包括高血压、高血糖、高胆固醇血症以及高循环甘油三酯水平。然而，最近的临床前研究已经确定了对抗心血管疾病的新方法。热量限制已在各种实验模型动物中反复证明可延长寿命。这导致了热量限制模拟物和其他能够延缓与年龄相关疾病的药物干预措施的开发。在这篇综述中，我们将探讨衰老本身对心血管系统的机制性影响，并关注支持心血管健康的各种治疗策略的延年益寿益处。
Zotero 插件