Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO 63110, USA.
FEBS Lett. 2011 Jun 6;585(11):1537-42. doi: 10.1016/j.febslet.2011.03.015. Epub 2011 Mar 12.
Life expectancy in the world has increased dramatically during the last century; the number of older adults is expected to rise while the number of youths will decline in the near future. This demographic shift has considerable public health and economic implications since aging is associated with the development of serious chronic diseases. Calorie restriction (CR) is the most effective nutritional intervention for slowing aging and preventing chronic disease in rodents. In non-human and human primates, CR with adequate nutrition protects against abdominal obesity, diabetes, hypertension and cardiovascular diseases. Cancer morbidity and mortality are also diminished in CR monkeys, and data obtained from individuals practicing long-term CR show a reduction of metabolic and hormonal factors associated with increased cancer risk.
上个世纪以来，全球的预期寿命显著延长；在不久的将来，老年人的数量预计会增加，而年轻人的数量将会减少。这种人口结构的转变对公共卫生和经济具有重大影响，因为老龄化与严重慢性疾病的发生发展相关。热量限制（CR）是减缓衰老和预防啮齿动物慢性疾病最有效的营养干预措施。在非人类灵长类动物中，充足营养的 CR 可预防腹部肥胖、糖尿病、高血压和心血管疾病。CR 猴子的癌症发病率和死亡率也有所降低，而从长期实行 CR 的个体中获得的数据表明，与癌症风险增加相关的代谢和激素因素减少。
