Mamedgasanov R M, Rakhmani S A
Probl Endokrinol (Mosk). 1989 Jan-Feb;35(1):19-21.
The time course of erythrocytic lipid peroxidation (LP) was studied in 55 patients with insulin independent diabetes mellitus aged 40 to 60 years LP was assessed by the content of malonic dialdehyde (MDA) and peroxidative hemolysis of erythrocytes (PHE). During diabetic decompensation LP activity was increased, especially in the presence of lower limb angiopathies. The authors assumed an idea of the involvement of LP products in the pathogenesis of vascular lesions. Diabetic compensation did not cause normalization of LP activity however the use of antioxidant (alpha-tocopherol acetate) led to a significant decrease in LP activity which can be of importance for the treatment of the early stages of diabetic angiopathies.
对55名年龄在40至60岁的非胰岛素依赖型糖尿病患者的红细胞脂质过氧化（LP）时间进程进行了研究。通过丙二醛（MDA）含量和红细胞过氧化溶血（PHE）评估LP。在糖尿病失代偿期间，LP活性增加，尤其是在存在下肢血管病变的情况下。作者推测LP产物参与血管病变发病机制。糖尿病代偿并未使LP活性恢复正常，然而，使用抗氧化剂（醋酸α-生育酚）导致LP活性显著降低，这对糖尿病血管病变早期阶段的治疗可能具有重要意义。
