University of Medicine, Lille, France.
CHU Lille, Department of Diabetology, Endocrinology, Metabolism and Nutrition, Lille University Hospital, Lille, France.
Front Endocrinol (Lausanne). 2022 Jun 22;13:916903. doi: 10.3389/fendo.2022.916903. eCollection 2022.
There are few published data on the putative association between the ABO blood group/rhesus (Rh) factor and the risk of developing gestational diabetes mellitus (GDM). Our aim was to explore the link between each one factor and GDM development.
All women having given birth at Lille University Medical Center (Lille, France) between August 1, 2017, and February 28, 2018, were tested for GDM, using the method recommended in the French national guidelines. The risk of GDM was assessed for each ABO blood group, each Rh phenotype and combinations thereof, using logistic regression models.
1194 women had at least one GDM risk factor. The percentage of GDM varied with the ABO group (p=0.013). Relative to group O women, group AB women were more likely to develop GDM (OR = 2.50, 95% CI [1.43 to 4.36], p=0.001). Compared with the Rh-positive O group, only the Rh-positive AB group had an elevated risk of developing GDM (OR = 3.02, 95% CI [1.69 to 5.39], p < 0.001).
Our results showed that Rh-positive group AB women have a greater risk of GDM. With a view to preventing GDM, at-risk individuals could be identified by considering the ABO blood group phenotype either as a single risk factor or in combination with other risk factors.
关于 ABO 血型/恒河猴（Rh）因子与妊娠糖尿病（GDM）风险之间的假定关联，已有少量文献报道。我们旨在探讨每个因素与 GDM 发展之间的联系。
2017 年 8 月 1 日至 2018 年 2 月 28 日期间，在里尔大学医疗中心（法国里尔）分娩的所有女性均接受 GDM 检测，使用法国国家指南推荐的方法。使用逻辑回归模型评估每种 ABO 血型、每种 Rh 表型及其组合与 GDM 风险之间的关联。
1194 名女性至少有一种 GDM 危险因素。GDM 的百分比因 ABO 组而异（p=0.013）。与 O 组女性相比，AB 组女性更有可能发生 GDM（OR=2.50，95%CI[1.43 至 4.36]，p=0.001）。与 Rh 阳性 O 组相比，只有 Rh 阳性 AB 组发生 GDM 的风险增加（OR=3.02，95%CI[1.69 至 5.39]，p<0.001）。
我们的结果表明，Rh 阳性 AB 组女性发生 GDM 的风险更高。为了预防 GDM，可以考虑将 ABO 血型表型作为单一危险因素或与其他危险因素结合起来，对高危个体进行识别。
