Kapitola J, Jahoda I, Kobos L, Knotová S
Sb Lek. 1989 Jan;91(1):11-5.
Retention of radioactive strontium 85Sr (18,5 kBq i.e. 0.5 microCi i.p.)--concerning the whole body and in distal epiphysis, distal metaphysis and in the thigh bone diaphysis--was followed up in two similar experiments for the period of 5-6 weeks in rats of both sexes and different age (younger category 40-45 days, older category 120-140 days). In both experiments bone retention 85Sr in older female rats is lower than in younger female rats. In male rats similar difference has not been constantly proved. Retention seems to be higher in female rats in comparison with males in the category of young rats. On the contrary in the category of older rats the retention is lower in female rats. In epiphysis and diaphysis of the thigh bone the differences are analogous to whole body differences; 85Sr reacts in the opposite way in distal metaphysis--retention is here extensively higher in older rats than in younger ones. The results obtained confirm the conclusion interesting from the point of view of clinical problem: avidity of the skelet to administered radioactive strontium is in younger female rats higher than in young male rats. However it is severely declining especially in female rats--in the second experiment as far as the level significantly lower than in male rats of the same older age category.
在两项相似的实验中，对不同年龄（年轻组40 - 45天，老年组120 - 140天）的雌雄大鼠进行了为期5 - 6周的放射性锶85Sr（腹腔注射18.5 kBq，即0.5微居里）在全身以及股骨远端骨骺、远端干骺端和骨干中的潴留情况跟踪。在两项实验中，老年雌性大鼠的骨中85Sr潴留量均低于年轻雌性大鼠。在雄性大鼠中，类似差异并未得到持续证实。在年轻大鼠类别中，雌性大鼠的潴留量似乎高于雄性大鼠。相反，在老年大鼠类别中，雌性大鼠的潴留量较低。在股骨的骨骺和骨干中，差异与全身差异类似；在远端干骺端，85Sr的反应相反——老年大鼠的潴留量在此处远高于年轻大鼠。所获结果证实了从临床问题角度来看很有趣的结论：年轻雌性大鼠骨骼对注入放射性锶的亲和力高于年轻雄性大鼠。然而，这种情况尤其在雌性大鼠中严重下降——在第二项实验中，降至明显低于同一年龄类别雄性大鼠的水平。
