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[关于大鼠血液循环年龄差异的进一步观察]

[Additional observations on age differences in the blood circulation in rats].

作者信息

Kapitola J, Jahoda I, Kobos L, Knotová S, Michalová K

机构信息

Laborator pro endokrinologii a metabolismus, Univerzity Karlovy, Praha.

出版信息

Sb Lek. 1989 Sep;91(8-9):259-64.

PMID:2562583
Abstract

By means of microparticles labelled by radioactive strontium 85Sr (3M, USA) the authors in two experiments established cardiac output and local blood flow through bones and certain other organs and tissues of rats in two distinct age categories (35 and 90 days, 45 and 110 days). The results of both experiments showed 1) significant decrease of blood flow in skull, lumbar vertebrae, distal epiphysis, distal metaphysis and thighbone diaphysis and tibia in older rats of both sexes (proof of previous results with 86Rb), 2) constantly significant decrease of blood flow through a skin sample taken from the ventral side of the trunk and 3) nonconstant increase of blood flow through kidneys of older rats. The causes of observed changes are not known, physiological importance to be supposed particularly as regards the circulatory changes in bones, is also not clear.

摘要

作者通过用放射性锶85Sr(美国3M公司)标记的微粒,在两个实验中测定了两个不同年龄组(35和90天、45和110天)大鼠的心输出量以及通过骨骼和某些其他器官及组织的局部血流量。两个实验的结果均显示:1)两性老年大鼠的颅骨、腰椎、远端骨骺、远端干骺端、股骨干和胫骨的血流量显著减少(证实了先前用86Rb得出的结果);2)取自躯干腹侧的皮肤样本的血流量持续显著减少;3)老年大鼠肾脏的血流量有非持续性增加。所观察到的这些变化的原因尚不清楚,其生理重要性,尤其是与骨骼循环变化相关的生理重要性,也不明确。

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1
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2
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