Huang Pan, Zhou Jianghua, Yin Yanan, Jing Wenjuan, Luo Biru, Wang Jiang
1Department of Gynecology and Obstetrics,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan,People's Republic of China.
2Department of the Center of Coordination and Innovation for Aging Care and Health Promotion of Sichuan,Chengdu Medical School,Chengdu 610041, Sichuan,People's Republic of China.
Br J Nutr. 2016 Jul;116(1):132-41. doi: 10.1017/S0007114516001720. Epub 2016 May 16.
We conducted a systematic review and meta-analysis to compare the effect of breast-feeding and formula-feeding on body composition of preterm infants. We searched the literature using PubMed, Cochrane Central Library Issue, Ovid (Medline), Embase and other resources such as Google Scholar, electronic databases and bibliographies of relevant articles; two reviewers collected and extracted data independently. All the authors assessed risk of bias independently using the Newcastle-Ottawa Scale (NOS). A fixed-effects meta-analysis was undertaken with RevMan 5 software (The Cochrane Collaboration) using the inverse variance method (P≥0·05; χ 2 test). In contrast, a random-effects meta-analysis was carried out. Altogether, 630 articles were identified using search strategy, and the references within retrieved articles were also assessed. A total of six studies were included in this systematic review. In formula-fed infants, fat mass was higher at term (mean difference 0·24 (95 % CI 0·17, 0·31) kg), fat-free mass was higher at 36 weeks of gestational (mean difference 0·12 (95 % CI 0·04, 0·21) kg) and the percentage of fat mass was higher at 36 weeks of gestation (mean difference 3·70 (95 % CI 1·81, 5·59) kg) compared with breast-fed infants. Compared with breast-feeding, formula-feeding is associated with altered body composition from birth to term in preterm infants. The effects of formula-feeding on preterm infant body composition from term to 12-month corrected age are inconclusive in our study. Well-designed studies are required in the future to explore the effects of formula-feeding compared with breast-feeding.
我们进行了一项系统评价和荟萃分析，以比较母乳喂养和配方奶喂养对早产儿身体成分的影响。我们使用PubMed、Cochrane中心对照试验注册库、Ovid（医学期刊数据库）、Embase以及其他资源（如谷歌学术）、电子数据库和相关文章的参考文献来检索文献；两名评价员独立收集和提取数据。所有作者均使用纽卡斯尔-渥太华量表（NOS）独立评估偏倚风险。使用RevMan 5软件（Cochrane协作网）采用逆方差法进行固定效应荟萃分析（P≥0·05；χ2检验）。相反，进行了随机效应荟萃分析。通过检索策略共识别出630篇文章，对检索到的文章中的参考文献也进行了评估。本系统评价共纳入六项研究。与母乳喂养的婴儿相比，配方奶喂养的婴儿足月时脂肪量更高（平均差异0·24（95%可信区间0·17，0·31）kg），孕36周时去脂体重更高（平均差异0·12（95%可信区间0·04，0·21）kg），孕36周时脂肪量百分比更高（平均差异3·70（95%可信区间1·81，5·59）kg）。与母乳喂养相比，配方奶喂养与早产儿从出生到足月时身体成分的改变有关。在我们的研究中，配方奶喂养对早产儿从足月到校正年龄12个月时身体成分的影响尚无定论。未来需要设计良好的研究来探索配方奶喂养与母乳喂养相比的影响。
