van der Molen E J, de Graaf G J, Spierenburg T J, Nabuurs M J, Baars A J, Jager L P
Experientia. 1986 Dec 1;42(11-12):1247-9. doi: 10.1007/BF01946407.
An exploratory study was made of the mechanisms underlying the toxic action of carbadox in young pigs: dehydration, loss of appetite and at autopsy seemingly specific and selective structural alterations of the glomerular zone of the adrenal cortex. Administration of carbadox in the feed, in dosages of 150 ppm (approximately 6 mg X kg-1 b. wt X day-1) caused a rapid decline in the plasma aldosterone levels (to 10% of control) followed by significant changes in the sodium and potassium levels in blood. Characteristic for the toxic action of carbadox are the rapid and seemingly selective and specific alterations in the aldosterone-releasing zona glomerulosa of the adrenals. Our results indicate that with carbadox a functional and possibly reversible extirpation of the adrenal zona glomerulosa can be achieved in pigs.
脱水、食欲不振，尸检时肾上腺皮质球状带出现看似特定且有选择性的结构改变。以150 ppm（约6毫克/千克体重/天）的剂量将卡巴多司添加到饲料中，导致血浆醛固酮水平迅速下降（降至对照水平的10%），随后血液中的钠和钾水平发生显著变化。卡巴多司毒性作用的特征是肾上腺醛固酮分泌球状带迅速出现看似有选择性和特异性的改变。我们的结果表明，使用卡巴多司可在猪身上实现肾上腺球状带功能性且可能可逆的切除。
