光学相干断层扫描血管造影测量视网膜和脉络膜毛细血管的血管密度

Vascular Density in Retina and Choriocapillaris as Measured by Optical Coherence Tomography Angiography.

作者信息

Wang Qian, Chan Szyyann, Yang Jing Yan, You Bing, Wang Ya Xing, Jonas Jost B, Wei Wen Bin

机构信息

Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Capital Medical University, Beijing, China.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University, Mannheim, Germany.

出版信息

Am J Ophthalmol. 2016 Aug;168:95-109. doi: 10.1016/j.ajo.2016.05.005. Epub 2016 May 14.

DOI:10.1016/j.ajo.2016.05.005

PMID:27183862

Abstract

PURPOSE

To measure the density of the superficial retinal small vessel network (SRSVN), superficial retinal capillary network (SRCN), deep retinal capillary network (DRCN), and choriocapillaris and the size of the foveal avascular zone (FAZ) in the superficial retinal layer in normal eyes.

DESIGN

Prospective observational cross-sectional study.

METHODS

In healthy Chinese volunteers, the retinal and choroidal vasculature was visualized by split-spectrum amplitude decorrelation angiography-associated optical coherence tomography (RTVueXR Avanti device; Optovue Inc, Fremont, California, USA).

RESULTS

Among 105 healthy participants (age: 35.9 ± 13.8 years) mean FAZ measured 0.35 ± 0.12 mm(2), and mean density of SRSVN, SRCN, DRCN, and choriocapillaris was 8.54% ± 0.92%, 31.8% ± 2.6%, 45.8% ± 3.3%, 44.4% ± 3.3%, and 44.5% ± 2.7%, respectively. In multivariate analysis, higher SRSVN density was associated with younger age (P = .001; standardized regression coefficient β: -0.28), male sex (P = .008; β: -0.23), lower SRCN density (P < .001; β: -0.40), and larger mean choriocapillaris vessel diameter (P = .001; β: 0.30). Higher SRCN density was correlated with male sex (P = .007; β: -0.19), lower SRSVN density (P < .001; β: -0.44), and higher density of the radial peripapillary capillary density (P = .004; β: 0.20). Higher DRCN density was correlated with younger age (P < .001; β: -0.31), female sex (P = .002; β: 0.22), higher SRCN density (P < .001; β: 0.38), and higher choriocapillaris density (P < .001; β: 0.39). Higher choriocapillaris network density in the central region was associated with higher DRCN density (P < .001; β: 0.43) and lower radial peripapillary capillary density (P = .005; β: -0.26). All retinal vascular parameters were not significantly correlated with axial length or subfoveal choroidal thickness.

CONCLUSIONS

The density of the macular vascular networks decreases with older age and is independent of axial length and subfoveal choroidal thickness in healthy individuals.

摘要

目的

测量正常眼视网膜浅层小血管网络（SRSVN）、视网膜浅层毛细血管网络（SRCN）、视网膜深层毛细血管网络（DRCN）和脉络膜毛细血管的密度，以及视网膜浅层中央无血管区（FAZ）的大小。

设计

前瞻性观察性横断面研究。

方法

在中国健康志愿者中，通过分谱振幅去相关血管造影联合光学相干断层扫描（RTVueXR Avanti设备；美国加利福尼亚州弗里蒙特市Optovue公司）观察视网膜和脉络膜血管系统。

结果

在105名健康参与者（年龄：35.9±13.8岁）中，平均FAZ为0.35±0.12mm²，SRSVN、SRCN、DRCN和脉络膜毛细血管的平均密度分别为8.54%±0.92%、31.8%±2.6%、45.8%±3.3%、44.4%±3.3%和44.5%±2.7%。多因素分析显示，较高的SRSVN密度与较年轻的年龄相关（P = 0.001；标准化回归系数β：-0.28）、男性（P = 0.008；β：-0.23）、较低的SRCN密度（P < 0.001；β：-0.40）以及较大的脉络膜毛细血管平均血管直径相关（P = 0.001；β：0.30）。较高的SRCN密度与男性相关（P = 0.007；β：-0.19）、较低的SRSVN密度（P < 0.001；β：-0.44）以及较高的视盘周围放射状毛细血管密度相关（P = 0.004；β：0.20）。较高的DRCN密度与较年轻的年龄相关（P < 0.001；β：-0.31）、女性（P = 0.002；β：0.22）、较高的SRCN密度（P < 0.001；β：0.38）以及较高的脉络膜毛细血管密度相关（P < 0.001；β：0.39）。中央区域较高的脉络膜毛细血管网络密度与较高的DRCN密度相关（P < 0.001；β：0.43）以及较低的视盘周围放射状毛细血管密度相关（P = 0.005；β：-0.26）。所有视网膜血管参数与眼轴长度或黄斑下脉络膜厚度均无显著相关性。