Oh Jaeryung, Baik Daniel Jinhag, Ahn Jaemoon
Department of Ophthalmology, College of Medicine, Korea University, Seoul, Republic of Korea.
Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
Eur J Ophthalmol. 2020 Jan;30(1):48-57. doi: 10.1177/1120672118816225. Epub 2018 Dec 5.
To quantify vascular and structural macular variables in healthy eyes and to investigate correlations between these variables and age using optical coherence tomography angiography.
A total of 261 eyes of 261 subjects with normal fundus were included. Central macular thickness, ganglion cell layer to inner plexiform layer thickness, outer retina layer thickness, subfoveal choroidal thickness, and choroidal vascularity index were measured using optical coherence tomography. Foveal avascular zone area, vascular density, and flow void area were measured using optical coherence tomography angiography.
Vascular density in the superficial capillary plexus was correlated with central macular thickness, ganglion cell layer to inner plexiform layer thickness, and outer retina layer thickness ( < 0.001, = 0.004, and < 0.001, respectively). Vascular density in the deep capillary plexus was correlated with central macular thickness and outer retina layer thickness ( = 0.003 and = 0.001, respectively). Vascular density of choriocapillaris was correlated with vascular density of superficial capillary plexus and deep capillary plexus ( < 0.001 and = 0.001, respectively).
Vascular density of choriocapillaris varies with retinal vascular density rather than the structure of choroid using optical coherence tomography angiography. In contrast, retinal vascular density changes as the retinal structure. Our results provide more information about the relationship between retina and choroid.
使用光学相干断层扫描血管造影术量化健康眼睛的血管和黄斑结构变量，并研究这些变量与年龄之间的相关性。
纳入261例眼底正常受试者的261只眼睛。使用光学相干断层扫描测量中心黄斑厚度、神经节细胞层至内网状层厚度、视网膜外层厚度、黄斑下脉络膜厚度和脉络膜血管指数。使用光学相干断层扫描血管造影术测量黄斑无血管区面积、血管密度和血流缺失面积。
浅表毛细血管丛中的血管密度与中心黄斑厚度、神经节细胞层至内网状层厚度和视网膜外层厚度相关（分别为<0.001、=0.004和<0.001）。深部毛细血管丛中的血管密度与中心黄斑厚度和视网膜外层厚度相关（分别为=0.003和=0.001）。脉络膜毛细血管的血管密度与浅表毛细血管丛和深部毛细血管丛的血管密度相关（分别为<0.001和=0.001）。
使用光学相干断层扫描血管造影术，脉络膜毛细血管的血管密度随视网膜血管密度变化，而非脉络膜结构变化。相比之下，视网膜血管密度随视网膜结构而变化。我们的结果提供了更多关于视网膜与脉络膜之间关系的信息。
