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Is surgery still the optimal treatment for stage I non-small cell lung cancer?手术仍然是 I 期非小细胞肺癌的最佳治疗方法吗?
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Stage I lung cancer-to operate or to radiate? that is the question.I期肺癌——选择手术还是放疗?这是个问题。
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本文引用的文献

1
Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?免疫疗法与立体定向消融放疗(ISABR):一种治愈性方法?
Nat Rev Clin Oncol. 2016 Aug;13(8):516-24. doi: 10.1038/nrclinonc.2016.30. Epub 2016 Mar 8.
2
Prospective Trial of Stereotactic Body Radiation Therapy for Both Operable and Inoperable T1N0M0 Non-Small Cell Lung Cancer: Japan Clinical Oncology Group Study JCOG0403.立体定向体部放疗治疗可手术和不可手术 T1N0M0 期非小细胞肺癌的前瞻性研究:日本临床肿瘤学组研究 JCOG0403。
Int J Radiat Oncol Biol Phys. 2015 Dec 1;93(5):989-96. doi: 10.1016/j.ijrobp.2015.07.2278. Epub 2015 Nov 11.
3
SABR vs surgery for NSCLC in the media.媒体报道中关于非小细胞肺癌的立体定向体部放疗与手术治疗对比
Lancet Oncol. 2015 Sep;16(9):e422. doi: 10.1016/S1470-2045(15)00230-2.
4
Lobectomy versus stereotactic body radiotherapy for stage I non-small cell lung cancer: Post hoc analysis dressed up as level-1 evidence?肺叶切除术与立体定向体部放疗治疗Ⅰ期非小细胞肺癌:事后分析能伪装成一级证据吗?
J Thorac Cardiovasc Surg. 2015 Sep;150(3):468-71. doi: 10.1016/j.jtcvs.2015.06.086. Epub 2015 Jul 14.
5
Do we know bad science when we see it?当我们看到糟糕的科学时,我们能识别出来吗?
J Thorac Cardiovasc Surg. 2015 Sep;150(3):472-3. doi: 10.1016/j.jtcvs.2015.07.032. Epub 2015 Jul 17.
6
Surgery versus SABR for resectable non-small-cell lung cancer.手术与立体定向消融放疗治疗可切除非小细胞肺癌的比较
Lancet Oncol. 2015 Aug;16(8):e372. doi: 10.1016/S1470-2045(15)00091-1.
7
Surgery versus SABR for resectable non-small-cell lung cancer.手术与立体定向消融放疗治疗可切除非小细胞肺癌的对比
Lancet Oncol. 2015 Aug;16(8):e370-1. doi: 10.1016/S1470-2045(15)00036-4.
8
SABR in early operable lung cancer: time for evidence.早期可手术肺癌的立体定向消融放疗:是时候拿出证据了。
Lancet Oncol. 2015 Jun;16(6):597-8. doi: 10.1016/S1470-2045(15)70225-1. Epub 2015 May 13.
9
Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials.立体定向消融放疗与肺叶切除术治疗可手术的Ⅰ期非小细胞肺癌:两项随机试验的汇总分析
Lancet Oncol. 2015 Jun;16(6):630-7. doi: 10.1016/S1470-2045(15)70168-3. Epub 2015 May 13.
10
Non-small cell lung cancer, version 1.2015.非小细胞肺癌临床实践指南(2015 年版)
J Natl Compr Canc Netw. 2014 Dec;12(12):1738-61. doi: 10.6004/jnccn.2014.0176.

手术仍然是 I 期非小细胞肺癌的最佳治疗方法吗?

Is surgery still the optimal treatment for stage I non-small cell lung cancer?

机构信息

1 Hunter Holmes McGuire VA Medical Center, Virginia Commonwealth University, Richmond, VA 23224, USA ; 2 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

出版信息

Transl Lung Cancer Res. 2016 Apr;5(2):183-9. doi: 10.21037/tlcr.2016.04.05.

DOI:10.21037/tlcr.2016.04.05
PMID:27183993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4858582/
Abstract

There is debate about what is the optimal treatment for operable stage I non-small cell lung cancer (NSCLC). Although surgery has been the standard of care for centuries, recent retrospective and prospective randomized studies indicated that stereotactic ablative radiotherapy (SABR) could be an option for this group of patients with similar survival and less toxicities. However, to change the standard of care, more studies are needed and participating ongoing larger randomized studies is the best approach to resolve this controversy.

摘要

对于可手术的 I 期非小细胞肺癌(NSCLC),哪种治疗方法最佳存在争议。尽管手术已成为数百年的治疗标准,但最近的回顾性和前瞻性随机研究表明,立体定向消融放疗(SABR)可能是这组患者的一种选择,其生存情况相似,毒性更小。然而,要改变治疗标准,还需要更多的研究,参与正在进行的更大规模的随机研究是解决这一争议的最佳方法。