Nilsen K H
N Z Med J. 1977 Jun 8;85(589):472-5.
Two cases of systemic lupus erythematosus (SLE) developing avascular bone necrosis are described. One case had eight separate areas involved (shouldres, hips, knees and both distal tibiae), which is the largest number in a single case of SLE yet reported. In both cases, at the onset of symptoms of necrosis in a new area, the antinuclear factor increased markedly compared to the preceding level. This indicates that the onset of the pathological process leading to necrosis is due to increased activity of the SLE rather than the steroid treatment.
本文描述了两例系统性红斑狼疮（SLE）并发无菌性骨坏死的病例。其中一例有八个不同部位受累（肩部、髋部、膝部及双侧胫骨远端），这是迄今报道的SLE单病例中受累部位最多的。在两例中，新部位出现坏死症状时，抗核因子较之前水平显著升高。这表明导致坏死的病理过程的发生是由于SLE活动增加，而非类固醇治疗所致。
