Department of Inorganic and Analytical Chemistry, University of Geneva , Quai Ernest-Ansermet 30, CH-1211 Geneva, Switzerland.
Anal Chem. 2016 Jun 7;88(11):5649-54. doi: 10.1021/acs.analchem.6b01085. Epub 2016 May 26.
We report on a plasticized polyurethane ionophore-based thin film material (of hundreds of nanometer thickness) for simultaneous voltammetric multianalyte ion activity detection triggered by the oxidation/reduction of an underlying poly(3-octylthiophene) film. This material provides excellent mechanical, physical, and chemical robustness compared to other polymers. Polyurethane films did not exhibit leaching of lipophilic additives after rinsing with a direct water jet and exhibited resistance to detachment from the underlying electrode surface, resulting in a voltammetric current response with less than <1.5% RSD variation (n = 50). In contrast, plasticized poly(vinyl chloride), polystyrene, and poly(acrylate) ionophore-based membranes of the same thickness and composition exhibited a significant deterioration of the signal after identical treatment. While previously reported works emphasized fundamental advancement of multi-ion detection with multi-ionophore-based thin films, polyurethane thin membranes allow one to achieve real world measurements without sacrificing analytical performance. Indeed, polyurethane membranes are demonstrated to be useful for the simultaneous determination of potassium and lithium in undiluted human serum and blood with attractive precision.
我们报告了一种基于增塑型聚氨酯离子载体的薄膜材料（厚度数百纳米），用于通过底层聚（3-辛基噻吩）薄膜的氧化/还原触发同时伏安多分析物离子活度检测。与其他聚合物相比，这种材料具有出色的机械、物理和化学稳定性。用水射流直接冲洗后，聚氨酯薄膜不会浸出亲脂性添加剂，并且不易从底层电极表面脱落，从而导致伏安电流响应的变化小于 <1.5%（n = 50）。相比之下，相同厚度和组成的增塑聚（氯乙烯）、聚苯乙烯和聚丙烯酸酯离子载体基膜在经过相同处理后，信号显著恶化。虽然以前的报告强调了基于多离子载体的薄膜进行多离子检测的基础进展，但聚氨酯薄膜允许在不牺牲分析性能的情况下实现实际测量。事实上，聚氨酯薄膜已被证明可用于同时测定未经稀释的人血清和血液中的钾和锂，具有吸引力的精度。
