Lyu Yan, Gan Shiyu, Bao Yu, Zhong Lijie, Xu Jianan, Wang Wei, Liu Zhenbang, Ma Yingming, Yang Guifu, Niu Li
School of Civil Engineering, c/o Center for Advanced Analytical Science, School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, China.
State Key Laboratory of Electroanalytical Chemistry, c/o Engineering Laboratory for Modern Analytical Techniques, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Membranes (Basel). 2020 Jun 23;10(6):128. doi: 10.3390/membranes10060128.
Wearable sensors based on solid-contact ion-selective electrodes (SC-ISEs) are currently attracting intensive attention in monitoring human health conditions through real-time and non-invasive analysis of ions in biological fluids. SC-ISEs have gone through a revolution with improvements in potential stability and reproducibility. The introduction of new transducing materials, the understanding of theoretical potentiometric responses, and wearable applications greatly facilitate SC-ISEs. We review recent advances in SC-ISEs including the response mechanism (redox capacitance and electric-double-layer capacitance mechanisms) and crucial solid transducer materials (conducting polymers, carbon and other nanomaterials) and applications in wearable sensors. At the end of the review we illustrate the existing challenges and prospects for future SC-ISEs. We expect this review to provide readers with a general picture of SC-ISEs and appeal to further establishing protocols for evaluating SC-ISEs and accelerating commercial wearable sensors for clinical diagnosis and family practice.
基于固体接触离子选择性电极（SC-ISEs）的可穿戴传感器，目前通过对生物流体中的离子进行实时、无创分析来监测人体健康状况，正吸引着广泛关注。随着电位稳定性和重现性的提高，SC-ISEs经历了一场变革。新型传感材料的引入、对理论电位响应的理解以及可穿戴应用极大地推动了SC-ISEs的发展。我们综述了SC-ISEs的最新进展，包括响应机制（氧化还原电容和双电层电容机制）、关键的固体传感材料（导电聚合物、碳及其他纳米材料）以及在可穿戴传感器中的应用。在综述结尾，我们阐述了SC-ISEs当前存在的挑战以及未来的前景。我们期望本综述能为读者提供SC-ISEs的总体概况，并呼吁进一步建立评估SC-ISEs的方案，加速用于临床诊断和家庭医疗的商用可穿戴传感器的发展。
