Di Rosa Michelino, Malaguarnera Lucia
Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy.
Pathobiology. 2016;83(5):228-42. doi: 10.1159/000444855. Epub 2016 May 18.
Chitinase 3 like-1 (CHI3L1) is a chitinase-like protein member of family 18 chitinases, expressed in innate immune cells and involved in endothelial dysfunction and tissue remodelling. Since CHI3L1 is highly expressed in a variety of inflammatory diseases of infectious and non-infectious aetiology, it is recognised as a non-invasive prognostic biomarker for inflammation. A variety of studies revealing the increase in CHI3L1 levels in obesity, insulin resistance and in pathological conditions, such as atherosclerosis, coronary artery disease, acute ischaemic stroke, nephropathy, diabetic retinopathy and osteolytic processes, have suggested that CHI3L1 may also play a critical role in the evolution and complication of diabetes mellitus (DM). In this review we highlight the impact of CHI3L1 expression in DM and its contribution to the complication of this disease.
几丁质酶3样蛋白1（CHI3L1）是18家族几丁质酶中的一种几丁质酶样蛋白成员，在先天免疫细胞中表达，参与内皮功能障碍和组织重塑。由于CHI3L1在各种感染性和非感染性病因的炎症性疾病中高度表达，它被认为是一种炎症的非侵入性预后生物标志物。各种研究揭示了肥胖、胰岛素抵抗以及动脉粥样硬化、冠状动脉疾病、急性缺血性中风、肾病、糖尿病视网膜病变和溶骨过程等病理状况下CHI3L1水平的升高，这表明CHI3L1可能在糖尿病（DM）的发展和并发症中也起关键作用。在这篇综述中，我们强调了CHI3L1表达在糖尿病中的影响及其对该疾病并发症的作用。
