NorthWest Centre of Advanced Drug Delivery (NoWCADD), Manchester Pharmacy School, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom.
Centre for Tissue Injury and Repair, Institute of Inflammation and Repair, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom.
Adv Drug Deliv Rev. 2016 Dec 15;107:60-81. doi: 10.1016/j.addr.2016.05.005. Epub 2016 May 14.
In the last 20years, the availability of precision chemical tools (e.g. controlled/living polymerizations, 'click' reactions) has determined a step change in the complexity of both the macromolecular architecture and the chemical functionality of biodegradable polyesters. A major part in this evolution has been played by the possibilities that controlled macromolecular branching offers in terms of tailored physical/biological performance. This review paper aims to provide an updated overview of preparative techniques that derive hyperbranched, dendritic, comb, grafted polyesters through polycondensation or ring-opening polymerization mechanisms.
在过去的 20 年中，精密化学工具（例如可控/活性聚合、“点击”反应）的出现极大地改变了可生物降解聚酯的高分子结构和化学功能的复杂性。在这一演变过程中，控制高分子支化提供的具有针对性的物理/生物性能的可能性起到了重要作用。本文综述了通过缩聚或开环聚合机制制备超支化、树枝状、梳状、接枝聚酯的方法。
