Cho Su Youn, Roh Hee Tae
Exercise Physiology Laboratory, Department of Physical Education, Yonsei University, Republic of Korea.
Department of Physical Education, College of Arts and Physical Education, Dong-A University, Republic of Korea.
J Phys Ther Sci. 2016 Apr;28(4):1355-8. doi: 10.1589/jpts.28.1355. Epub 2016 Apr 28.
[Purpose] The aim of the present study was to investigate the effects of aerobic exercise training on the levels of peripheral brain-derived neurotrophic factor and eotaxin-1 in obese young men. [Subjects and Methods] The subjects included sixteen obese young men with a body mass index greater than 25 kg/m(2). They were randomly divided between control and exercise groups (n = 8 in each group). The exercise group performed treadmill exercise for 40 min, 3 times a week for 8 weeks at the intensity of 70% heart rate reserve. Blood collection was performed to examine the levels of serum glucose, plasma malonaldehyde, serum brain-derived neurotrophic factor, and plasma eotaxin-1 before and after the intervention (aerobic exercise training). [Results] Following the intervention, serum BDNF levels were significantly higher, while serum glucose, plasma MDA, and plasma eotaxin-1 levels were significantly lower than those prior to the intervention in the exercise group. [Conclusion] Aerobic exercise training can induce neurogenesis in obese individuals by increasing the levels of brain-derived neurotrophic factor and reducing the levels of eotaxin-1. Alleviation of oxidative stress is possibly responsible for such changes.
[目的]本研究旨在探讨有氧运动训练对肥胖青年男性外周脑源性神经营养因子和嗜酸性粒细胞趋化因子-1水平的影响。[对象与方法]研究对象为16名体重指数大于25 kg/m(2)的肥胖青年男性。他们被随机分为对照组和运动组（每组n = 8）。运动组以心率储备的70%为强度，每周进行3次跑步机运动，每次40 分钟，共8周。在干预（有氧运动训练）前后采集血液，检测血清葡萄糖、血浆丙二醛、血清脑源性神经营养因子和血浆嗜酸性粒细胞趋化因子-1水平。[结果]干预后，运动组血清BDNF水平显著升高，而血清葡萄糖、血浆MDA和血浆嗜酸性粒细胞趋化因子-1水平显著低于干预前。[结论]有氧运动训练可通过提高脑源性神经营养因子水平和降低嗜酸性粒细胞趋化因子-1水平，诱导肥胖个体的神经发生。氧化应激的减轻可能是导致这些变化的原因。
